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首页> 美国政府科技报告 >Cytokine Response to Subclinical Cytomegalovirus Reactivation as a Cause of Severe Fatigue in Women Undergoing Chemotherapy for Breast Cancer.
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Cytokine Response to Subclinical Cytomegalovirus Reactivation as a Cause of Severe Fatigue in Women Undergoing Chemotherapy for Breast Cancer.

机译：细胞因子对亚临床巨细胞病毒再激活的反应是乳腺癌化疗妇女严重疲劳的原因。

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This is the annual report for the first year of this grant. The goal of this grant is to study 26 women undergoing chemotherapy for breast cancer, assessing their fatigue levels before, during and after treatment, and correlating fatigue with CMV serostatus, the immune response to CMV, and cytokine levels. During this first year we completed the technical arrangements for the study and enrolled the first 9 patients. 4 are CMV seronegative, and 5 are seropositive. Fatigue survey data, serum, PBMC and urine have been collected and stored. We will collect four time points on each patient. One patients has completed the study, the others are in progress. During this year we performed quality control tests on PBMC preservation, and established our initial panel of antibodies to be used for intracellular cytokine staining and FACS analysis. Patient recruitment has been proceeding at an acceptable pace and no problems are anticipated in recruiting the full study cohort within the allotted time. Furthermore, our patients are fairly equally distributed between CMV seropositives and seronegatives, which gives best statistical power for the study and optimizes our likelihood of recruiting the full patient cohort.

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