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首页> 美国政府科技报告 >Correlation of Airway Hyper-responsiveness with Obstructive with Spirometric Indices and FEV1 > 90% Predicted.
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Correlation of Airway Hyper-responsiveness with Obstructive with Spirometric Indices and FEV1 > 90% Predicted.

机译：气道高反应性与阻塞性肺活量指数和FEV1> 90％预测的相关性。

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摘要

Current published guidelines on spirometry interpretation suggest an elevated FVC and FEV(sub 1) > 100% of predicted with an obstructive ratio may represent a physiological variant. There is minimal evidence whether this finding can be indicative of symptomatic airways obstruction. Pulmonary function testing databases for a 4-year period were retrospectively reviewed. All technically adequate spirometry studies were included, based on these criteria: FEV(sub 1) > 90% of predicted, and FEV(sub 1)/FVC below the lower limit of normal, based on 95th percentile confidence intervals. Clinical indications for testing were noted. Testing for postbronchodilator response, lung volumes, and methacholine challenge tests were reviewed for evidence of airway hyper-responsiveness (AHR). Comparisons were made between symptomatic versus asymptomatic individuals and FEV(sub 1) values less than or greater than 100% of predicted. RESULTS: A total of 280 studies were analyzed. During their clinical evaluation, 192 patients (69%) had post-bronchodilator spirometry recorded, 63 patients (23%) had lung volumes, and 36 patients (11%) completed methacholine challenge testing. Indications for spirometry included 193 symptomatic patients and 87 asymptomatic patients. Nearly 28% of patients with postbronchodilator testing met criteria for AHR. No differences in AHR were found between the symptomatic and asymptomatic groups. The majority of patients (77%) with AHR had an FEV(sub 1).

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