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首页> 美国政府科技报告 >Circulating Antibodies to Mouse Laminin in Chagas Disease, American Cutaneous Leishmaniasis, and Normal Individuals Recognize Terminal Galactosyl(alpha 1-3)-Galactose Epitopes
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Circulating Antibodies to Mouse Laminin in Chagas Disease, American Cutaneous Leishmaniasis, and Normal Individuals Recognize Terminal Galactosyl(alpha 1-3)-Galactose Epitopes

机译：在恰加斯病，美国皮肤利什曼病和正常个体的小鼠层粘连蛋白的循环抗体识别末端半乳糖基（α1-3） - 半乳糖表位

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Patients with Chagas disease develop antibodies reacting with blood vessels, endocardium, striated muscle, and peripheral nerves and these antibodies are thought to be involved in the development of degenerative changes in various organs. A large glycoprotein found exclusively in basement membranes was able to bind most of the tissue-reacting antibodies present in these sera. Sera from patients with American cutaneous leishmaniasis and Chagas disease and from monkeys infected with either Trypanosoma cruzi or Trypanosoma rhodesiense show, in radioimmunoassays, strong binding to mouse laminin. A distinct although weaker binding activity is also detected in normal human sera. The antibodies recognize a common carbohydrate epitope present on mouse laminin, which was assigned to a terminal galactosyl(alpha 1-3)-galactose group. Distinct crossreactions were observed with some other basement membrane proteins, rabbit glycosphingolipids, defucosylated human B blood group substance and components produced by some human tumor cells. Only little activity was, however, found on laminin obtained from human placenta. The data indicate that the antibodies arising in infectious diseases are simulated by similar carbohydrate epitopes present on the surface of parasites. Tissue-specific occurrence of such epitopes may exist and explain the involvement of distinct tissues in autoimmune disorders. Reprints. (AW)

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