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首页> 美国政府科技报告 >Cerebellar Purkinje Cell Activity Related to the Classically Conditioned Nictitating Membrane Response
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Cerebellar Purkinje Cell Activity Related to the Classically Conditioned Nictitating Membrane Response

机译：小脑浦肯野细胞活动与经典条件的瞬膜反应有关

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Because of the purported critical role of cerebellar lobule HVI in classical conditioning of the nicitating membrane response of the rabbit, the authors recorded extracellularly from HVI Purkinje cells (PCs) during differential conditioning. Rabbits were trained using tonal conditioned stimuli (CSs) and stimulation of the periocular region as the unconditioned stimulus (US). Many PCs responded to the US, the most frequently observed being a burst of simple spikes. PCS in HVI showed a variety of responses to CSS that were related to the conditioned response (CRs). The most frequently observed response was an increase in simple spikes correlated with CRs. The activity of many of these cells antedated CRs by 20-200ms. A smaller proportion that antedated CRs. The existence of PCs that alter their firing before CRs suggests that they may be causally involved in this behavior, and in this respect they reinforce reports that lesions of HVI or its connections disrupt nicitating membrane CRs. Although complex spike activity was not generally related to the US or to CRs, a few PCs responded in relation to CRs with only complex spikes. In demonstrating CR-related activity in cerebellar PCs, this study supports theories of cerebellar learning such as those of Marr and Albus.

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