首页> 美国政府科技报告 >Evaluation of Serum Creatine Kinase and Lactate Dehydrogenase in Experimental Myocardial Infarction, Atriotomies, and Thoracotomies
【24h】

Evaluation of Serum Creatine Kinase and Lactate Dehydrogenase in Experimental Myocardial Infarction, Atriotomies, and Thoracotomies

机译:实验性心肌梗死,atriotomies和胸腔切开术中血清肌酸激酶和乳酸脱氢酶的评价

获取原文

摘要

Myocardial infarction causes elevation of the serum myocardial-specific isoenzyme of creatine kinase (CK-MB) and a serum isoezyme of lactic dehydrogenase (LDH1). Since atrial myocardium has as much CK-MB as ventricular myocardium, surgical manipulation of the atrium could cause elevation of serum CK-MB in the post-operative period. The distribution of LDH isoenzymes is different between atrial and ventricular myocardium. Hence, surgical procedures on the atrium could, theoretically, cause different changes in serum LDH isoenzymes than those seen after acute myocardial infarction. This study was conducted to ascertain whether surgical manipulation of the atrium could cause changes in these two serum enzyme systems that might be confused with those seen after acute myocardial infarction. Right thoracotomies were performed on 20 dogs. Each dog then was assigned randomly to one of four groups: thoracotomy (control), placement of atrial pursestring sutures, atriotomy, or acute perioperative myocardial infarction. Serum total a isoenzyme distributions of Ck and LDH were measured for 48 hours in all animals. The results suggest that significant elevations of serum CK-MB occured even after small atriotomies. Confirmation of a ventricular myocardial origin of postoperative serum CK-MB bands was obtained by analysis of serum LDH isoenzymes in that the ratio of LDH 1 to LDH2 and the absolute value of serum LDH1 became elevated only after acute perioperative myocardial infarction and not after atriotomy.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号