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首页> 美国政府科技报告 >Effect of Gamma-Irradiation on the Healing of Gastric Biopsy Sites in Monkeys: An Experimental Model for Peptic Ulcer Disease and Gastric Protection
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Effect of Gamma-Irradiation on the Healing of Gastric Biopsy Sites in Monkeys: An Experimental Model for Peptic Ulcer Disease and Gastric Protection

机译：γ射线照射对猴子胃活检部位愈合的影响：消化性溃疡病和胃保护的实验模型

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The acute effects of gamma-irradiation on the gastric mucosa have been studied in a primate model. Fiberoptic gastroscopies were performed in 6 rhesus monkeys in the basal state as well as 3 h and 3, 7, and 9 days after total body irradiation (800 rads). Gastric biopsy specimens (diameter 1 mm) obtained during each session were examined using light microscopy and scanning electron microscopy; in addition, subsequent healing of the biopsy sites was assessed visually. Gastric biopsy sites were completely healed in 3 days in the basal state; in contrast, ulcer craters (diameter 1 mm) microscopic were still present at the site of the biopsies 3, 7, and 9 days after the biopsies were performed in irradiated animals. Light microcopic examination of the biopsy specimens demonstrated only lymphocytic infiltration of the lamina propria. In contrast, scanning electron microscopic examination revealed that the size and number of microvilli of the gastric surface epithelial cells were increased onthe day of irradiation compared to basal; 3-9 days later, numerous gastric surface epithelial cells were damage or had dissappeared so that bare areas of the lamina propria were visible in the specimens taken outside of the ulcer craters.

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