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Metabolic Fate of Liposomal Phosphatidylinositol in Murine Tumor Cells: Implications for the Mechanism of Tumor Cell Cytotoxicity

机译：小鼠肿瘤细胞中脂质体磷脂酰肌醇的代谢命运：对肿瘤细胞细胞毒性机制的影响

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The mechanism of the previously reported cytotoxicy of liposomes containing plant phosphatidylinositol (Pl) against numerous tumor cell lines was examined in detail by using liposomes containing synthetic Pl specifically labeled either with radioactive myo-inosositol, or in the sn-2 position with radioactive linoleic acid, oleic acid, or arachidonic acid. The uptake of liposomal Pl by N4TG1 neuroblastoma cells increased with time and was dependent on the nature of the fatty acids. Uptake was highest with liposomal Pl containig linoleic acid followed by arachidonic acid and then by oleic acid. The cellular fate of liposomal Pl was determined by analysis of radioactive metabolites present in extracts of tumor cell lipids. Appearance of liposomal Pl metabolic products in the tumor cells was correlated with thymidine uptake as a measure of viability. The amount of Pl containing linoleic acid in the sn-2 position could be correlated with a decrease in the amount of thymidine uptake by tumor cells. The above results clearly established that phospholipases A2 and C in the tumor cells were responsible for the formation of metabolites of liposomal Pl, and these metabolic products might have been responsible for cytotoxicity and cell death.

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Jett, M.; Chudzik, J.; Alving, C. R.; Stanacev, N. Z.;
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年度 1985
页码 p.1-8
总页数 8
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Metabolism; Neoplasms; Chemotherapeutic agents; Cells(Biology); Cytoplasm; Cytotoxin; Death; Fatty acids; Linoleic acid; Lipids; Metabolites; Oleic acid; Pathology; Radioactivity; Thymidines; Viability; Reprints;

机译：代谢;肿瘤;化学治疗剂;细胞（生物学）;细胞质;细胞毒素;死亡;脂肪酸;亚油酸;脂质;代谢物;油酸;病理学;放射性;胸苷;活力;重印;

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8. Metabolic Fate of Liposomal Phosphatidylinositol in Murine Tumor Cells: Implications for the Mechanism of Tumor Cell Cytotoxicity. [R] . Jett, M., Chudzik, J., Alving, C. R., 1985

机译：小鼠肿瘤细胞中脂质体磷脂酰肌醇的代谢命运：对肿瘤细胞细胞毒性机制的影响。

Metabolic Fate of Liposomal Phosphatidylinositol in Murine Tumor Cells: Implications for the Mechanism of Tumor Cell Cytotoxicity

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