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首页> 美国政府科技报告 >L-Tryptophan Administered to Chronic Sleep-Onset Insomniacs: Late-Appearing Reduction of Sleep Latency
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L-Tryptophan Administered to Chronic Sleep-Onset Insomniacs: Late-Appearing Reduction of Sleep Latency

机译：L-色氨酸治疗慢性睡眠型失眠症：睡眠潜伏期延迟出现

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The effects of 3 g 1-tryptophan on sleep, performance, arousal threshold, and brain electrical activity during sleep were assessed in 20 male, chronic sleep-onset insomniacs (mean age 20.3 + or - 2.4 years). Following a sleep laboratory screening night, all subjects received placebo for 3 consecutive nights (single-blind), 10 subjects received 1-tryptophan and 10 subjects received placebo on 2 withdrawal nights (single-blind). There was no effect of 1-tryptophan on sleep latency during the first 3 nights of administration. ON the 4th-6th nights of administration, sleep latency was significantly reduced. Unlike benzodiazepine hypnotics, 1-tryptophan did not alter sleep stages, impair performance, elevate arousal threshold, or alter brain electrical activity during sleep.

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