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Stability of Epinephrine in Dental Anesthetic Solutions: Implications for Autoclave Sterilization and Elevated Temperature Storage

机译：牙科麻醉剂中肾上腺素的稳定性：对高压灭菌器灭菌和高温储存的影响

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Epinephrine is the least stable component of local anesthetic solutions and therefore the limiting factor for elevated temperature storage. Autoclave sterilization seems to be limited by the carpule's physical ability to withstand autoclave conditions. Our work confirms previous studies reporting only limited epinephrine decomposition during a few autoclave cycles. The calculated epinephrine concentration curves presented, for elevated temperature storage and autoclaving, agree with published data. These curves can be used to approximate the epinephrine concentration changes expected for various storage temperatures and times.

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作者
Kelly, J. R.; Dalm, G. W.;
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年度 1985
页码 p.1-9
总页数 9
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Anesthetics; Epinephrine; Shelf life; Autoclaves; Cycles; Dentistry; High temperature; Limitations; Physical properties; Stability; Sterilization; Storage; Temperature; Thermal stability; Thermal cycling tests; Reprints;

机译：麻醉剂;肾上腺素;保质期;高压灭菌器;周期;牙科;高温;局限性;物理性质;稳定性;灭菌;储存;温度;热稳定性;热循环试验;重印;

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1. The storage stability of melamine formaldehyde resin solutions: III. Storage at elevated temperatures [J] . S. Jahromi Polymer: The International Journal for the Science and Technology of Polymers . 1999,第18期

机译：三聚氰胺甲醛树脂溶液的储存稳定性：III。高温储存
2. Forced degradation studies of norepinephrine and epinephrine from dental anesthetics: Development of stability-indicating HPLC method and in silico toxicity evaluation [J] . Letfcia Coli Louvisse de Abreu, Barbara de Azevedo Abrahim-Vieira, Alessra Mendonga Teles de Souza, Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2020,第7期

机译：从牙科麻醉药中脱甲肾上腺素和肾上腺素的强制降解研究：稳定性表明HPLC方法和硅毒性评价的发展
3. Felypressin, but not epinephrine, reduces myocardial oxygen tension after an injection of dental local anesthetic solution at routine doses. [J] . Inagawa M, Ichinohe T, Kaneko Y Journal of Oral and Maxillofacial Surgery . 2010,第5期

机译：在常规剂量的牙科局部麻醉剂注射后，非加压素（而非肾上腺素）可降低心肌的氧张力。
4. An experimental study of the stability of uranyl and U(IV) chloride aqueous complexes at elevated temperatures: implications to the mobility of U in natural systems [C] . Artaches A. Migdisov, Alexander Timofcev, Hakim Boukhalfa Rare Earth Research Conference . 2019

机译：升温铀酰和U（IV）氯化物含水络合物稳定性的实验研究：对自然系统中U的流动性的影响
5. Measuring the effects of elevated temperatures and carbon dioxide fertilization on soil carbon storage. [D] . Hensel, Theresa Lynn. 1999

机译：测量高温和二氧化碳施肥对土壤碳储量的影响。
6. Epinephrine magnesium and dental local anesthetic solutions. [O] . J. G. Meechan 1996

机译：肾上腺素镁和牙科局部麻醉药。
7. Felypressin, but not epinephrine, reduces myocardial oxygen tension after an injection of dental local anesthetic solution at routine doses [O] . Inagawa, M, Ichinohe, T, Kaneko, Y 2010

机译：Felypressin，但不是肾上腺素，在常规剂量注射牙科局部麻醉剂溶液后可降低心肌氧张力
8. Volume of Anesthetic in 0.5% Marcaine with 1:200,000 Epinephrine Dental Carpule. [R] . Jones, B. 2016

机译：0.5％马卡因与1：200,000肾上腺素牙釉质的麻醉剂量。

Stability of Epinephrine in Dental Anesthetic Solutions: Implications for Autoclave Sterilization and Elevated Temperature Storage

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