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Molecular Interactions of High Energy Fuels and Jet Fuels with Oncogenic Viruses and Endogenous Viruses

机译：高能燃料和喷气燃料与致癌病毒和内源性病毒的分子相互作用

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The objectives of this research were to develop rapid in-vitro assays, to evaluate the carcinogenic potential of chemicals used by the U.S. Air Force. Snyder-Theilen Feline Sarcoma Virus (ST-FeSV), quantitatively transforms human skin fibroblasts following second order kinetics. These studies were performed in order to determine whether chemicals altered ST-FeSV transformation in a predictable manner and to correlate the alteration with the carcinogenic or non-carcinogenic activity of the test chemical. The results, to date, show diverse carcinogens classed as: aromatic amines, polycyclic hydrocarbons, aminofluorenes, hydrazines, asbestos and mycotoxins inhibited virus transformation when virus infected cells (2 hours post-infection) were exposed to test chemical, while non-carcinogenic chemicals had no significant effect on transformation. Triton X-100, acetone, petroleum and shale oil derived JP5; RJ5 and diesel fuel, marine, demonstrated non-carcinogenic activity while formalin demonstrated carcinogenic activity. Experiments designed to show the specificity of the antagonistic effect of known carcinogens are reported.

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