• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Peptidoglycans as Promoters of Slow-Wave Sleep. II. Somnogenic and Pyrogenic Activities of Some Naturally Occurring Muramyl Peptides; Correlations with Mass Spectrometric Structure Determination
【24h】

Peptidoglycans as Promoters of Slow-Wave Sleep. II. Somnogenic and Pyrogenic Activities of Some Naturally Occurring Muramyl Peptides; Correlations with Mass Spectrometric Structure Determination

机译：peptidoglycans作为慢波睡眠的促进剂。 II。一些天然存在的胞壁酰肽的致嗜性和致热活性;与质谱结构测定的相关性

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The structures of components of the sleep-promoting material purified from human urine were established by fast atom bombardment-mass spectrometry. We report here that two substances isolated from that preparation, viz. (N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramoyl-Ala-gamma-Glu- diaminopimeloyl-Ala) and that compound lacking the terminal alanine, are active as somnogens. Cerebro-intraventricular administration of 1 pmol of the glycotetrapeptide was sufficient to induce prolonged excess sleep in rabbits. Findings show that in addition to the muramyl form of peptidoglycan monomers, the anhydro muramyl form, with no reducing end, is compatible with somnogenic activity. Furthermore, the data obtained with a natural product amplify our earlier observations with smaller synthetic molecules of the importance of amidation/deamidation in the structure-activity relationships of muramyl peptides.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号