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首页> 美国政府科技报告 >Effectiveness of Aprotinin in Blocking a Shock Factor of Pancreatic Origin from the Pig, Dog, or Monkey
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Effectiveness of Aprotinin in Blocking a Shock Factor of Pancreatic Origin from the Pig, Dog, or Monkey

机译：抑肽酶阻断猪，狗或猴胰腺来源休克因子的有效性

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摘要

Pancreatic shock factor (PSF) causes profound hypotension when injected into the species of origin (i.e. 'within species', pig PSF into the pig, etc.). Aprotinin, a proteolytic enzyme inhibitor, sucessfully blocked the PSF-induced hypotension 'within species' in the pig but did not alter the hypotension in the dog or monkey. This investigated by infusing PSF from either the pig, dog, or monkey into the other two species ('across species'). PSF was a hypotensive agent 'across species'; aprotinin blocked the hypotensive reaction in each 'across species' combination. Aprotinin is more effective as a blocking agent of PSF when infused 'across' then 'within species'. These species differences of the aprotinin blockade should be considered when designing treatment for shock associated with proteolytic enzymes.

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