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Relationship between Esmolol and the Onset and Duration of Action of Succinylcholine in Patients Undergoing General or Orthopedic Surgery.

机译：艾司洛尔与琥珀胆碱在普通或整形外科患者中的发作和作用持续时间的关系。

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The purpose of this study was to investigate a potential interaction between esmolol and succinylcholine. Specifically, the researcher investigated whether or not esmolol prolongs the onset and duration of action of succinylcholine (Sch). The investigator studied 25 adult, ASA I and II, male and female patients. Patients underwent orthopedic or general surgical procedures under general anesthesia requiring endotracheal intubation. All subjects received identical preoperative medication; glycopyrrolate 0.2 mg intravenous (IV). Statistical analysis revealed a significant slowing in onset of Sch induced muscle relaxation (p<.045). Conversely, there was no statistically significantly delay in 50% (p<.179) and 90% recovery (p<.109). However, statistical analysis indicated that esmolol did prolong the recovery from Sch induced neuromuscular blockade. Further investigation of this potential interaction is warranted. Keywords: Beta blockers; Theses. (KT)

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作者
Safara, P. J.;
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年度 1983
页码 1-80
总页数 80
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Anesthesia; Orthopedics; Surgery; Females; Interactions; Intubation; Muscles; Nerve blocking; Neuromuscular transmission; Patients; Relaxation(Physiology); Statistical analysis; Theses; Esmolol; Succinylcholine; Pharmacology;

机译：麻醉;骨科;外科;女性;相互作用;气管插管;肌肉;神经阻滞;神经肌肉传导;患者;放松（生理学）;统计分析;论文;艾司洛尔;琥珀胆碱;药理学;

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Relationship between Esmolol and the Onset and Duration of Action of Succinylcholine in Patients Undergoing General or Orthopedic Surgery.

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