Activation of Membrane-Bound Kallikrein and Renin in the Kidney

机译：肾结合激活膜结合激肽释放酶和肾素

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Rat kidney contains membrane-bound renin and kallikrein. Kallikrein activity was measured with a spectrophotometric assay and renin by radioimmunoassay. Plasma membrane-bound kallikrein was activated by lysolecithin and also by melittin, which was a more potent activator. This activation by mellitin was independent of calcium concentration. Melittin was, however, a more potent activator of bound-renin in the presence of calcium. Administration of aldosterone to rats for six days increased kallikrein activity in the renal homogenate and in the membrane-enriched fractions, while renin activity was not affected. It was proposed that kallikrein may be located also on the basal membrane of tubular epithelial cells, where aldosterone can enhance its activity. (Author)

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Nishimura, K.; Alhenc-Gelas, F.; White, A.; Erdos, E. G.;
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年度 1980
页码 p.1-26
总页数 26
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Renin; Activation; Membranes(Biology); Kidneys; Rats; Chemical reactions; Aldosterone;

机译：肾素;激活;膜（生物学）;肾;大鼠;化学反应;醛固酮;

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1. Mechanism of acid-activation of renin: role of kallikrein in renin activation. [J] . W A Hsueh, E J Carlson, M Israel-Hagman Hypertension: An Official Journal of the American Heart Association . 1981,第3aPta2期

机译：肾素的酸激活机制：激肽释放酶在肾素激活中的作用。
2. Activation of membrane-bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases [J] . Dong Ying, Harrington Brittney S., Adams Mark N., Biological chemistry . 2014,第9期

机译：膜结合蛋白和受体系统的激活：组织激肽释放酶和与KLK相关的肽酶之间的联系
3. Effects of diabetes and insulin on expression of kallikrein and renin genes in the kidney [J] . Ayad A Jaffa, Karl X Chai, Julie Chao, Kidney international. . 1992,第4期

机译：糖尿病和胰岛素对肾中激肽释放酶和肾素基因表达的影响
4. The renin-angiotensin and kinin-kallikrein systems between industrial and informational epochs. Conflict of defensive programmes: Pathogenic or sanogenic? [C] . Vitalie Scripnic, Aurel Saulea, Leonid Churilov, IEEE International Conference on E-Health and Bioengineering . 2015

机译：工业和信息时代之间的肾素-血管紧张素和激肽-激肽释放酶系统。防御计划冲突：致病还是致病？
5. Modifiers of the Kidney Response to Activation of the Renin-Angiotensin System: ACE2 and Adiponectin. [D] . Fang, Fei. 2014

机译：肾对肾素-血管紧张素系统活化反应的调节剂：ACE2和脂联素。
6. Activation of membrane-bound kallikrein and renin in the kidney. [O] . K Nishimura, F Alhenc-Gelas, A White, 1980

机译：肾脏中结合膜的激肽释放酶和肾素的激活。
7. Activation of membrane-bound kallikrein and renin in the kidney. [O] . Nishimura, K, Alhenc-Gelas, F, White, A, 1980

机译：肾脏中结合膜的激肽释放酶和肾素的激活。

Activation of Membrane-Bound Kallikrein and Renin in the Kidney

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