首页> 美国政府科技报告 >Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-37220, 1-(3-Cyclohexen-1-Ylcarbonyl)-2-Methylpiperidine and AI3-37224,1-(3-Cyclohexen-1-Ylcarbonyl)-1,2,3,6-Tetrahydropyridine

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Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-37220, 1-(3-Cyclohexen-1-Ylcarbonyl)-2-Methylpiperidine and AI3-37224,1-(3-Cyclohexen-1-Ylcarbonyl)-1,2,3,6-Tetrahydropyridine

机译：候选驱虫剂aI3-37220，1-（3-环己烯-1-基羰基）-2-甲基哌啶和aI3-37224,1-（3-环己烯-1-基羰基）-1,2,3的局部危害评估程序， 6-四氢吡啶

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Preliminary hazard evaluations of AI3-37220 and AI3-37224 were performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. The technical grade of compounds caused mild skin and eye irritation, but no phototoxic or sensitization reactions. Neither compound proved to be acutely toxic by ingestion. (Author)

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Singer, A. W.;
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年度 1980
页码 p.1-9
总页数 9
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Insect repellents; Toxicity; Toxic hazards; Piperidines; Pyridines; Eye; Skin(Anatomy); Irritation; Rats; Rabbits; Guinea pigs; Test and evaluation;

机译：驱虫剂;毒性;有毒危害;哌啶类;吡啶类;眼睛;皮肤（解剖学）;刺激性;大鼠;兔;豚鼠;测试和评估;

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1. A neuroprotective agent, T-817MA (1-{3-(2-(1-benzothiophen-5-yl)ethoxy)propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. [J] . Kawasaki T, Ago Y, Kitao T, Neuropharmacology . 2008,第5期

机译：一种神经保护剂T-817MA（1- {3-（2-（1-（1-苯并噻吩-5-基）乙氧基）丙基}氮杂环丁烷-3-醇马来酸酯）可以预防1-甲基-4-苯基-1,2 3，6-四氢吡啶诱导的小鼠神经毒性。
2. Synthesis of 1-(substituted phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydropyridine-5-carboxylic acid diethylamides as potential anti-inflammatory agents [J] . Gangapuram M, Redda KK Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2006,第3期

机译：1-（取代的苯基羰基/磺酰氨基）-1,2,3,6-四氢吡啶-5-羧酸二乙酰胺的合成作为潜在的抗炎药
3. Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4- phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel blockers with antinociceptive effect in a neuropathic pain model [J] . LeeJ.-H., SeoS.H., LimE.J., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2014,第Null期

机译：1-（异恶唑-5-基甲基氨基乙基）-4-苯基四氢吡啶和哌啶衍生物的合成和生物学评价作为有效的T型钙通道阻滞剂，在神经性疼痛模型中具有镇痛作用
4. Product formulations and in vitro - in vivo evaluation of (1) Topical insect repellent formulations against mosquitoes; (2) Oral sustained release formulations of cefaclor and pentoxifylline in adults [D] . Chou, Joyce Tian-wei 1996

机译：产品配方和体外-体内评价（1）局部驱蚊剂对付蚊子；（2）成人头孢克洛和己酮可可碱的口服缓释制剂
5. Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice [O] . Minjuan Bian, Jie Liu, Xiaoqi Hong, 2009

机译：1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的小鼠帕金过表达改善多巴胺能神经变性
6. Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. [O] . Minjuan Bian, Jie Liu, Xiaoqi Hong, 2012

机译：帕金的过表达改善小鼠中由1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的多巴胺能神经变性。
7. Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-37221 and AI3-37225, 1-(3-cyclohexen-1-ylcarbonyl)-3-methylpiperidine and 1-(3-cyclohexen-1-ylcarbonyl)-4-methylipiperazine [R] . Singer, A. W. 1980

机译：候选驱虫剂aI3-37221和aI3-37225，1-（3-环己烯-1-基羰基）-3-甲基哌啶和1-（3-环己烯-1-基羰基）-4-甲基哌嗪的局部危害评估程序

Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-37220, 1-(3-Cyclohexen-1-Ylcarbonyl)-2-Methylpiperidine and AI3-37224,1-(3-Cyclohexen-1-Ylcarbonyl)-1,2,3,6-Tetrahydropyridine

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