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首页> 美国政府科技报告 >Mammalian Toxicity of Munitions Compounds. Phase I. Acute Oral Toxicity,Primary Skin and Eye Irritation, Dermal Sensitization,Disposition and Metabolism and Ames Tests of Additional Compounds.
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Mammalian Toxicity of Munitions Compounds. Phase I. Acute Oral Toxicity,Primary Skin and Eye Irritation, Dermal Sensitization,Disposition and Metabolism and Ames Tests of Additional Compounds.

机译：弹药化合物的哺乳动物毒性。第一阶段。急性口服毒性，原发性皮肤和眼睛刺激，皮肤过敏，处置和代谢以及其他化合物的ames试验。

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Tests indicated that 3,5-Dinitrotoluene (3,5-DNT) was the most potent of all DNT isomers in oral acute doses to rats and mice. 2-Amino-4, 6-DNT (2-ADNT) and its isomer, 4-ADNT, were the least potent in rats and female mice, and comparable to 2,3-DNT and 2,4-DNT in male mice. 3.5-DNT and 4-ADNT were not irritating to rabbit skin; 2-ADNT was a mild irritant. All three compounds were not irritating to rabbit eyes and not sensitizing to guinea pigs. 3,5-DNT and 4-ADNT were absorbed from the gastrointestinal tract, metabolized and excreted in the urine. In the Ames test, 1,3-dinitroglycerin (1,3-DNG), 1-mononitroglycerin (1-MNG), nitrocellulose and white phosphorus were not mutagenic. Trinitrotoluene (TNT) 2,4-DNT, 2,5-DNT, tetranitromethane (TNM) and 1,2-DNG were mutagenic at 10 to 30 microgram/plate in one or more strains. TNM was bactericidal without activation. 1,2-DNG was nonmutagenic with activation. 2,3-DNT, 2,6-DNT, 3,5-DNT, trinitroglycerin and 2-MNG were weakly mutagenic, with mutagenic results at 100 or 1,000 microgram/plate in one or more strains.

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