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Immunogenicity of One Dose of Vero Cell Culture-Derived Japanese Encephalitis (JE) Vaccine in Adults Previously Vaccinated with Mouse Brain-Derived JE Vaccine.

机译：一剂Vero细胞培养衍生的乙型脑炎（JE）疫苗在先前用小鼠脑源性JE疫苗接种的成人中的免疫原性。

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Background: There are no data on the use of inactivated Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) as a booster among individuals who previously received inactivated mouse brain-derived JE vaccine (JE-MB). Methods: Military personnel who received 3 doses of JE-MB or were JE vaccine-na ve were vaccinated with 2 doses of JE-VC on days 0 and 28. Serum neutralizing antibodies were measured pre-vaccination and 28 days after each dose. Non-inferiority was evaluated for seroprotection rate and geometric mean titer (GMT) between previously vaccinated participants post-dose 1 and vaccine-na ve participants post-dose 2. Results: Fifty-three previously vaccinated and 70 JE vaccine-na ve participants were enrolled. Previously vaccinated participants had significantly higher GMTs pre-vaccination, post-dose 1, and post-dose 2. Seroprotection rates among previously vaccinated participants post-dose 1 (44/44, 100%) were noninferior to those achieved in previously na ve participants post-dose 2 (53/57, 93%). The GMT was significantly higher in previously vaccinated participants post-dose 1 (GMT 315; 95% CI 191 520) compared to previously na ve participants post-dose 2 (GMT 79; 95% CI 54 114). Conclusions: Among military personnel previously vaccinated with 3 doses of JE-MB, a single dose of JE-VC adequately boosts neutralizing antibody levels and provides at least short-term protection. Additional studies are needed to confirm these findings in other populations and determine the duration of protection following a single dose of JE-VC in prior recipients of JE-MB.

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Woolpert, T.; Staples, J. E.; Faix, D. J.; Nett, R. J.; Kosoy, O. I.; Biggerstaff, B. J.; Johnson, B. W.; Sracic, M.; Fischer, M.;
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年度 2012
页码 1-9
总页数 9
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Cells(biology); Immunogens; Japanese encephalitis; Vaccines; Cultures(biology); Demography; Dosage; Immunization; Military personnel; Protection; Statistical analysis; Vero cell culture-derived je vc; Immunogenicity; Je vc(japanese encephalitis vaccines); Je mb(mouse brain-derived je vaccines); Seroprotection; Je(japanese encephalitis); 60501;

机译：细胞（生物学）;免疫原;日本脑炎;疫苗;培养物（生物学）;人口学;剂量;免疫;军事人员;保护;统计分析; Vero细胞培养衍生物;免疫原性; Je vc（日本脑炎疫苗）; Je mb（小鼠脑源性je疫苗）;血清保护; Je（日本脑炎）; 60501;

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专利

1. Long-term immunogenicity of an initial booster dose of an inactivated, Vero cell culture-derived Japanese encephalitis vaccine (JE-VC) and the safety and immunogenicity of a second JE-VC booster dose in children previously vaccinated with an inactivated, mouse brain-derived Japanese encephalitis vaccine [J] . Yun Ki Wook, Lee Hoan Jong, Park Ji Young, Vaccine . 2018,第11期

机译：初始加强剂的长期免疫原性，灭活的Vero细胞培养衍生的日本脑炎疫苗（JE-VC）以及先前用灭活的小鼠脑接种的儿童的第二次JE-VC增强剂剂量的安全性和免疫原性 - 衍生的日本脑炎疫苗
2. Immunogenicity of one dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine [J] . Woolpert Tabitha, Staples J. Erin, Faix Dennis J., Vaccine . 2012,第20期

机译：一剂Vero细胞培养源性日本脑炎（JE）疫苗对先前接种过小鼠脑源性JE疫苗的成年人的免疫原性
3. Immune response at 12-23 months following a single dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine [J] . Krow-Lucal Elisabeth R., Laven Janeen, Perry Lori, Vaccine . 2020,第44期

机译：在以前用小鼠脑衍生的JE疫苗接种疫苗的成人疫苗的单剂量Vero细胞培养衍生的日本脑炎（JE）疫苗后，在12-23个月内免疫反应
4. Overcoming Graft-vs.-Host Disease in the Humanized Mouse and Using Natural Killer T cell Activation as an Adjuvant in an Epstein-Barr Virus Vaccine. [D] . Lockridge, Jennifer. 2013

机译：在人源化小鼠中克服移植物抗宿主病，并在爱泼斯坦-巴尔病毒疫苗中使用自然杀伤性T细胞活化作为佐剂。
5. A Single Dose of Vero Cell–Derived Japanese Encephalitis (JE) Vaccine (Ixiaro) Effectively Boosts Immunity in Travelers Primed With Mouse Brain–Derived JE Vaccines [O] . Elina O. Erra, Helena Hervius Askling, Lars Rombo, -1

机译：单一剂量的Vero细胞衍生的日本脑炎（JE）疫苗（Ixiaro）可有效增强以小鼠脑衍生的JE疫苗引发的旅行者的免疫力
6. A Single Dose of Vero Cell-Derived Japanese Encephalitis (JE) Vaccine (Ixiaro) Effectively Boosts Immunity in Travelers Primed With Mouse Brain-Derived JE Vaccines [O] . E. O. Erra, H. H. Askling, L. Rombo, 2012

机译：单一剂量的Vero细胞衍生的日本脑炎（JE）疫苗（IXIARO）有效地提高了在用小鼠脑衍生的JE疫苗灌注的旅行者中的免疫力

Immunogenicity of One Dose of Vero Cell Culture-Derived Japanese Encephalitis (JE) Vaccine in Adults Previously Vaccinated with Mouse Brain-Derived JE Vaccine.

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