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Evaluation of Vascular Clearance as a Marker for Virulence of Alphaviruses: Disassociation of Rapid Clearance with Low Virulence of Venezuelan Encephalitis Virus Strains in Guinea Pigs.

机译：评估血管清除作为甲病毒毒力的标志物：快速清除与委内瑞拉脑炎病毒株在豚鼠中的低毒力的解离。

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In the present study, using guinea pigs, six of six virulent strains of Venezuelan encephalitis virus (VEE) were cleared inefficiently, while three of six nonlethal or benign virus strains were cleared rapidly. However, three other guinea pigs-benign VEE strains cleared slowly, like lethal strains. The inability of one benign virus strain, which cleared slowly, to produce a high viremia was correlated with inefficient growth in primary viral replication sites. Thus, while the low virulence of certain alphavirus strains may depend primarily on rapid clearance (e.g., TC-83, VEE vaccine in the hamster), the low virulence of other alphaviruses may depend on factors other than vascular clearance.

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Jahrling, P. B.; Heisey, G. B.; Hesse, R. A.;
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年度 1977
页码 1-20
总页数 20
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Venezuelan equine encephalomyelitis virus; Virulence; Guinea pigs; Growth(Physiology); Clearances; Virus diseases; Lethality;

机译：委内瑞拉马脑脊髓炎病毒;毒力;豚鼠;生长（生理学）;清除;病毒病;致死率;

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1. Evaluation of vascular clearance as a marker for virulence of alphaviruses: disassociation of rapid clearance with low virulence of venezuelan encephalitis virus strains in guinea pigs. [J] . P B Jahrling, G B Heisey, R A Hesse Infection and immunity . 1977,第2期

机译：评价血管清除率作为α病毒毒力的标志物：快速清除与豚鼠委内瑞拉脑炎病毒株的低毒力无关。
2. Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice [J] . Bernard KA., Johnston RE., Klimstra WB. Virology . 2000,第1期

机译：委内瑞拉马脑炎病毒的E2糖蛋白突变赋予硫酸乙酰肝素相互作用，低发病率和从小鼠血液中快速清除
3. Genetic Diversity of Venezuelan Alphaviruses and Circulation of a Venezuelan Equine Encephalitis Virus Subtype JAB Strain During an Interepizootic Period [J] . Medina Gladys, Garzaro Domingo J., Barrios Miguel, The American Journal of Tropical Medicine and Hygiene . 2015,第1期

机译：委内瑞拉病毒之间的遗传多样性和委内瑞拉马脑炎病毒亚型JAB株的流通。
4. Evaluation of vascular clearance as a marker for virulence of alphaviruses: disassociation of rapid clearance with low virulence of venezuelan encephalitis virus strains in guinea pigs. [O] . P B Jahrling, G B Heisey, R A Hesse 1977

机译：评价血管清除率作为α病毒毒力的标志物：快速清除率与豚鼠委内瑞拉脑炎病毒株的低毒力无关。
5. Mutations in the E2 Glycoprotein of Venezuelan Equine Encephalitis Virus Confer Heparan Sulfate Interaction, Low Morbidity, and Rapid Clearance from Blood of Mice [O] . Bernard Kristen A., Klimstra William B., Johnston Robert E. 2000

机译：委内瑞拉马脑炎病毒的E2糖蛋白突变赋予硫酸乙酰肝素相互作用，低发病率和从小鼠血液中快速清除

Evaluation of Vascular Clearance as a Marker for Virulence of Alphaviruses: Disassociation of Rapid Clearance with Low Virulence of Venezuelan Encephalitis Virus Strains in Guinea Pigs.

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