Experimental Septic Shock: Models and Mechanisms.

机译：实验性感染性休克：模型和机制。

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The present study was designed to develop a nonhuman primate model more relevant to the clinical entity of septic shock. Experiments were conducted on young adult baboons, unrestrained, and maintained at a light plane of pentobarbital anesthesia. Responses of animals infused with E. coli endotoxin or live E. coli organisms were evaluated during a 24-hour period or until death. Results suggest significant differences between the two shock models: large dosages of endotoxin on contrast to those used in the canine species were required to elicit lethality characteristics. Hypoglycemia and hypoinsulinemia were regularly observed in live E. coli organism induced shock; however, hyperglycemia was a consistent hallmark in the endotoxin infused model. Renal fibrin thrombi were presented only after E. coli administration while tubular necrosis was found following both organism and endotoxin infusions.

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Hinshaw, L. B.; Benjamin, B.; Holmes, D. D.; Beller, B.; Archer, T.;
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年度 1976
页码 1-31
总页数 31
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Shock(Pathology); Escherichia coli; Bacterial toxins; Models; Baboons; Anesthesia; Lethality; Pulmonary function; Glucose; Insulin; Liver; Kidneys; Metabolism; Blood coagulation; Septic shock; Animal models; Papio anubus; Experimental data; Primates;

机译：休克（病理学）;大肠杆菌;细菌毒素;模型;狒狒;麻醉;致死率;肺功能;葡萄糖;胰岛素;肝;肾;代谢;血液凝固;感染性休克;动物模型;狒狒狒狒;实验数据;灵长类动物;

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Experimental Septic Shock: Models and Mechanisms.

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