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首页> 美国政府科技报告 >Embryonal Carcinoma of the Ovary. A Clinicopathologic Entity Distinct from Endodermal Sinus Tumor Resembling Embryonal Carcinoma of the Adult Testis.
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Embryonal Carcinoma of the Ovary. A Clinicopathologic Entity Distinct from Endodermal Sinus Tumor Resembling Embryonal Carcinoma of the Adult Testis.

机译：卵巢的胚胎癌。一种临床病理实体，与成人睾丸胚胎癌相似的内胚层窦瘤不同。

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The clinical and pathologic features of 15 examples of a hitherto undescribed germ cell tumor of the ovary are delineated. This tumor resembles the enbryonal carcinoma of the adult testis and may be distinguished from the endodermal sinus tumor on the basis of its histologic and immunohistochemical characteristics. An indirect immunoperoxidase method for the localization of human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) was done on formalin-fixed paraffin-embedded tissue from 10 neoplasms; HCG was present in all 10 neoplasms, and AFP was found in seven. HCG was identified only in cells resembling syncytiotrophoblast, whereas AFP was present only in mononuclear embryonal cells, indicating that the two protein antigens were localized in different cell types. Abnormal hormonal manifestation, consisting of precocious puberty, irregular bleeding, amenorrhea, or hirsutism, were present in nine (60%) of the patients.

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