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Rosette Formation between Human Lymphocytes and Sheep Erythrocytes: Inhibition of Rosette Formation by Specific Glycopeptides.

机译：人淋巴细胞和绵羊红细胞之间的玫瑰花结形成：通过特异性糖肽抑制玫瑰花结形成。

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Rosette formation with unsensitized sheep erythrocytes is a characteristic of human t-lymphocytes. Tryptic glycopeptides inhibit Rosette formation by untrypsinized sheep erythrocytes suggesting that Rosetting is mediated by erythrocyte surface glycopeptides. To investigate the molecular nature of this interaction, the abilities of various model compounds to act as haptenic inhibitors of Rosette formation was investigated. Among compounds tested, fetuin glycopeptide is most effective, but human transferrin glycopeptide and human erythrocyte glycopeptide I also inhibit Rosette formation. Fetuin glycopeptide blocks Rosette formation when added to a suspension of human lymphocytes and sheep erythrocytes, or when preincubated with human lymphocytes, but not when preincubated with sheep erythrocytes. Compared to normals, lymphocytes from patients with chronic lymphatic leukemia demonstrate decreased fetuin glycopeptide binding. This decreased binding correlates with the impaired ability of these cells to form Rosettes. The data suggest that fetuin glycopeptide inhibits Rosette formation by binding to the T-cell where competition occurs with sheep erythrocytes for specific lymphocyte surface receptors.

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Boldt, D. H.; Armstrong, J. P.;
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年度 1975
页码 1-13
总页数 13
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Rosette scan; Lymphocytes; Glycoproteins; Sheep; Blood cells; Immunity; Serology; Inhibition; Humans; Reprints; T cells; Fetuin glycopeptides;

机译：玫瑰花结扫描;淋巴细胞;糖蛋白;绵羊;血细胞;免疫;血清学;抑制;人类;重印; T细胞;胎球蛋白糖肽;

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专利

1. Human autologous mixed lymphocyte reactivity is primarily specific for xenoprotein determinants adsorbed to antigen-presenting cells during rosette formation with sheep erythrocytes. [J] . C Huber, M Merkenschlager, C Gattringer, The Journal of Experomental Medicine . 1982,第4期

机译：人自体混合淋巴细胞反应性主要针对在与绵羊红细胞形成玫瑰花结期间吸附到抗原呈递细胞的异种蛋白决定簇。
2. Combined Detection of Human T and B Lymphocytes by Rosette Formation with Sheep Erythrocytes and Zymosan-C3 Complexes [J] . Nelson F. Mendes, Silvia S. Miki, Zulma F. Peixinho The journal of immunology . 1974,第2期

机译：玫瑰红细胞与羊红细胞和酵母聚糖-C3复合体联合检测人T和B淋巴细胞。
3. Rosette formation assays in dogs: lack of specificity of E rosettes for T lymphocytes. [J] . S Krakowka, D J Guyot Infection and immunity . 1977,第1期

机译：狗的玫瑰花结形成测定：E玫瑰花结对T淋巴细胞缺乏特异性。
4. Immunological synapses formation: rosettes between human autologous cultured monocyte-maerophages and lymphocytes [C] . Novak I., Cabral H. European Congress of Immunology . 2009

机译：免疫突触形成：人体自体培养单核细胞和淋巴细胞之间的玫瑰花
5. (2'-5')PPP3'DA(P3'DA)(N') A STRUCTURAL MODIFICATION OF (2'-5')PPPA(PA)(N): ENZYMATIC SYNTHESIS, CHARACTERIZATION, AND INHIBITION OF CELLULAR TRANSFORMATION IN EPSTEIN-BARR VIRUS-INFECTED LYMPHOCYTES. [D] . DOETSCH, PAUL WILLIAM. 1982

机译：（2'-5'）PPP3'DA（P3'DA）（N'）（2'-5'）PPPA（PA）（N）的结构修饰：酶合成，表征和抑制蛋白中的细胞转化-BARR病毒感染的淋巴细胞。
6. Rosette formation between human lymphocytes and sheep erythrocytes. Inhibition of rosette formation by specific glycopeptides. [O] . D H Boldt, J P Armstrong 1976

机译：人淋巴细胞和绵羊红细胞之间形成玫瑰花结。特定糖肽抑制玫瑰花结的形成。
7. Rosette formation between human lymphocytes and sheep erythrocytes. Inhibition of rosette formation by specific glycopeptides. [O] . Boldt, D H, Armstrong, J P 1976

机译：人淋巴细胞和绵羊红细胞之间形成玫瑰花结。特定糖肽抑制玫瑰花结的形成。
8. Inhibition of Human Lymphocyte Transformation by Human alpha -Fetoprotein (Hafp): Studies on the Mode of Hafp Action and the Role of Hafp Polymorphism [R] . Lester, E. P., Miller, J. B., Yachnin, S. 1977

机译：人α-甲胎蛋白（Hafp）对人淋巴细胞转化的抑制作用：Hafp作用模式及Hafp多态性的作用研究

Rosette Formation between Human Lymphocytes and Sheep Erythrocytes: Inhibition of Rosette Formation by Specific Glycopeptides.

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