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Capillary Density in Developing and Healing Tuberculous Lesions Produced by BCG in Rabbits.

机译:家兔BCG发生和愈合结核病灶的毛细血管密度。

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Dermal tuberculous lesions were produced in rabbits by the intradermal injection of BCG. At various times after infection, anesthetized animals were perfused with a gelatin-colloidal carbon medium via the abdominal aorta. The capillary density of the nonnecrotic granulation tissue in the lesions was determined quantitatively by counting the capillaries under an ocular grid of a microscope. The capillary density in normal skin near the lesions was 3.8 + or - 0.5 in millimeters of capillary lengths per square millimeter in 250-micrometer tissue section. The capillary density of the nonnecrotic tissue in BCG lesions averaged 6.11 + or - 0.6 mm/sq mm, an increase of 60%. The capillary density remained more or less constant as the BCG lesions grew and then regressed. The development of delayed hypersensivity seemed to increase the capillary density, but this increase may have been a response to an extension of the necrosis at the time delayed hypersensitivity developed. Capillary densities in tuberculin reactions resembled those in BCG lesions. In the early stages, the increased capillary network of dermal BCG lesions was derived mainly from the subpapillary vascular plexus surrounding the hair follicles. As the lesions grew, the cutaneous vascular plexus of the deep dermis supplied branches that surrounded the lower half of the caseous necrotic center and anastomosed with capillaries from the subpapillary plexus supplying the upper half.

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