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首页> 美国政府科技报告 >Optical Activity and Conformation of Carbohydrates. Ii. Optical Rotatory Dispersion and Circular Dichroism Studies on Immunochemically Reactive Oligo- and Polysaccharides Containing Amino Sugars and Their Derivatives
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Optical Activity and Conformation of Carbohydrates. Ii. Optical Rotatory Dispersion and Circular Dichroism Studies on Immunochemically Reactive Oligo- and Polysaccharides Containing Amino Sugars and Their Derivatives

机译：碳水化合物的光学活性和构象。二。含有氨基糖及其衍生物的免疫化学反应性寡糖和多糖的旋光色散和圆二色性研究

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Optical rotatory dispersion and circular dichroism spectra of several mono- and oligosaccharides are presented, as well as spectra samples of teichoic acid, N-acetylneuraminic acid, N-acetylneuraminyllactose, and colominic acid, a polymer comprising repeating units of N-acetylneuraminic acid. Attention is focused on the optical activity generated by the 2-acetamido chromophore, common to all compounds examined. The circular dichroism spectra confirm the reality and spectral location of the Cotton effects in those optical rotatory dispersion spectra which have been previously reported. On the basis of the size of the Cotton effect troughs of these compounds and of other oligosaccharides whose rotations are given in previously published reports, it is possible to arrange the oligosaccharides containing N-acety-D-glucosamine residues into three groups. Tentative rules are proposed which may allow decisions to be made as to the nature and position of substituents on N-acetyl-D-glucosamine residues in oligo- and polysaccharides. It is shown that the N-acetyl-D-glucosamine residues in teichoic acids dominate the shape and largely determine the intensity of optical rotatory dispersion spectra of these polymers. The great differences in spectra of colominic acid and of its constituent N-acetylneuraminic acid suggest a conformational dependence of the optically active absorption bands in the polymer. This finding and the possible applicability of the work reported here to diverse immunochemical studies are discussed. (Author)

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