Tropine-Labeled Atropine Metabolism in Man n-C14H3-Atropine

机译：man n-C14H3-阿托品中Tropine标记的阿托品代谢

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

The excretion of the C14 in the urine and expired air, and the disappearance of the C14 from the blood after an intramuscular injection of 2 mg. are discussed in this report. Chromatographic analysis of urinary components is incomplete, but preliminary data suggests that most of the label is present in the urine as unchanged atropine and as its hydrolysis product, tropine. A total of 88% of the injected dose was collected in the urine in 48 hours. A unique finding was the occurrence of C14 in the expired air, indicative of a demethylation being one of the metabolic pathways for atropine in man. Approximately 3% of the injected dose was recovered in the expired air in the 3 hours during which samples were taken. Blood levels were extremely low, indicative of avid tissue binding of the drug, but did seem to reach a maximum at 30 minutes after injection, a time at which maximum tachycardia was also observed. Expired air C14O2 showed a maximum at 75 minutes, while the peak urinary concentration occured at 3 hours. (Author)

著录项

作者
Kalser, S. C.; McLain, P. L.;
展开▼
作者单位

展开▼
年度 1967
页码 p.1-7
总页数 7
原文格式 PDF
正文语种 eng
中图分类
关键词
Atropine ; Metabolism ; Labeled substances ; Tolerances(Physiology) ; Excretion ; Tracer studies ; Electrocardiography ; Blood chemistry ; Urine ; Chromatographic analysis;

机译：阿托品;代谢;标记物质;耐受性（生理学）;排泄;示踪研究;心电图;血液化学;尿液;色谱分析;

相似文献

外文文献
中文文献
专利

1. Enzymology of oxidation of tropic acid to phenylacetic acid in metabolism of atropine by Pseudomonas sp. strain AT3. [J] . M T Long, B A Bartholomew, M J Smith, Journal of bacteriology . 1997,第4期

机译：假单胞菌sp。假单胞菌代谢阿托品的过程中将乙酸氧化为苯乙酸的酶学。菌株AT3。
2. Atropine Metabolism by Pseudomonas sp. Strain AT3: Evidence for Nortropine as an Intermediate in Tropine Breakdown and Reactions Leading to Succinate. [J] . B A Bartholomew, M J Smith, P W Trudgill, Applied and Environmental Microbiology . 1996,第9期

机译：假单胞菌属阿托品代谢。菌株AT3：降冰片中间体和导致琥珀酸酯反应的证据-降冰片。
3. Low-concentration atropine for myopia progression (LAMP) study Phase 2: 0.05% atropine remained the best concentration among 0.05%, 0.025%, and 0.01% atropine over 2 years [J] . Yam Jason, Li Fen Fen, Tang Shu Min, Investigative ophthalmology & visual science . 2019,第9期

机译：近视近视的低浓度阿托品（灯）研究阶段2：0.05％阿托品在2年内，0.05％，0.025％和0.01％阿巴罗的最佳浓度
4. Technoeconomic MINLP Optimisation of Liquid-Liquid Extraction (LLE) Cascades for Continuous Pharmaceutical Manufacturing (CPM) of Atropine [C] . Samir Diab, Nikolaos Mytis, Andreas G.Boudouvis European Symposium on Computer Aided Chemical engineering . 2019

机译：用于阿托品连续药物制造（CPM）的液 - 液萃取（LLE）级联的技术经济MINLP优化
5. Enhancing the Sublingual Permeability of Atropine Sulfate: Effect of pH and Penetration Enhancers [D] . Bafail, Rawan. 2019

机译：增强阿托哌酸酯的舌下渗透性：pH和渗透增强剂的作用
6. Enzymology of oxidation of tropic acid to phenylacetic acid in metabolism of atropine by Pseudomonas sp. strain AT3. [O] . M T Long, B A Bartholomew, M J Smith, 1997

机译：假单胞菌sp。假单胞菌代谢阿托品的过程中将乙酸氧化为苯乙酸的酶学。菌株AT3。
7. Enzymology of oxidation of tropic acid to phenylacetic acid in metabolism of atropine by Pseudomonas sp. strain AT3. [O] . Long, M T, Bartholomew, B A, Smith, M J, 1997

机译：假单胞菌sp。假单胞菌代谢阿托品的过程中将乙酸氧化为苯乙酸的酶学。菌株AT3。

Tropine-Labeled Atropine Metabolism in Man n-C14H3-Atropine

摘要

著录项

相似文献

相关主题

期刊订阅