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Immunotherapy of Prostate Cancer With Genetically Enhanced Tumor- Specific T-Cell Precursors

机译：用遗传增强的肿瘤特异性T细胞前体免疫治疗前列腺癌

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Precursor (Pre) T cells, when adoptively transferred further develop in the thymus into mature T cells, that is capable of lysing tumors. The overall objective of this project is to develop an effective off the shelf adoptive cell therapy with PreT cells targeting prostate cancer. To enhance the anti-tumor activity of PreT cells we transduced these cells with a chimeric antigen receptor (CAR)-Pz1 targeting the prostate cancer associated antigen - prostate specific membrane antigen (PSMA). Here we show that prostate cancer specific PreT cells can be generated by expressing CARs targeting human PSMA. T cells derived from the adoptively transferred PreT cells develop in thymic and extrathymic sites and prolong survival of prostate cancer bearing recipients.

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作者
Brink, M.;
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年度 2011
页码 1-7
总页数 7
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Antigens ; Membranes(Biology) ; Prostate cancer ; T lymphocytes ; Cells(Biology) ; Immunotherapy ; Neoplasms ; Passenger vehicles ; Precursors ; Prostate gland ; Targeting ; Therapy ; Thymus;

机译：抗原;膜（生物学）;前列腺癌; T淋巴细胞;细胞（生物学）;免疫疗法;肿瘤;乘用车;前体;前列腺;靶向;治疗;胸腺;

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专利

1. Efficacy Against Human Prostate Cancer by Prostate-specific Membrane Antigen-specific, Transforming Growth Factor-beta Insensitive Genetically Targeted CD8(+) T-cells Derived from Patients with Metastatic Castrate-resistant Disease [J] . Zhang Qiang, Helfand Brian T., Carneiro Benedito A., European urology . 2018,第5期

机译：通过前列腺特异性膜抗原特异性对人前列腺癌进行疗效，转化生长因子-β不敏感的遗传靶向CD8（+）T细胞衍生自转移性溶胀性疾病的患者
2. Combining DNA Vaccine and AIM2 in H1 Nanoparticles Exert Anti-Renal Carcinoma Effects via Enhancing Tumor- Specific Multi-functional CD8(+) T-cell Responses [J] . Chai Dafei, Shan Hongjian, Wang Gang, Molecular cancer therapeutics . 2019,第2期

机译：将DNA疫苗和AIM2组合在H1纳米粒子中通过增强肿瘤特异性多功能CD8（+）T细胞应答来施加抗肾癌作用
3. Rescue of Notch-1 Signaling in Antigen-Specific CD8+ T Cells Overcomes Tumor-Induced T-cell Suppression and Enhances Immunotherapy in Cancer [J] . Rosa A. Sierra, Paul Thevenot, Patrick L. Raber, Cancer immunity . 2014,第8期

机译：抗原特异性CD8 + T细胞中Notch-1信号的挽救克服了肿瘤引起的T细胞抑制并增强了癌症的免疫疗法。
4. Prostate Cancer-Specific mAb 5D4 Significantly Enhances the Cytotoxicity of Doxorubicin-Loaded Liposomes Against Target Cells In Vitro [C] . Rishikesh M. Sawant, Michael B. Cohen, Vladimir P. Torchilin, Controlled Release Society Annual Meeting and Exposition . 2007

机译：前列腺癌特异性mAb 5D4显着增强了阿霉素脂质体对靶细胞的体外细胞毒性
5. Studies on human prostate-specific antigen as a tumor antigen for the immunotherapy of prostate cancer in a mouse model. [D] . Willis, Richard Allen. 2002

机译：人类前列腺特异性抗原作为一种肿瘤抗原的免疫模型在小鼠模型中的研究。
6. Efficacy Against Human Prostate Cancer by Prostate-specific Membrane Antigen-specific Transforming Growth Factor-β Insensitive Genetically Targeted CD8+ T-cells Derived from Patients with Metastatic Castrate-resistant Disease [O] . Qiang Zhang, Brian T. Helfand, Benedito A. Carneiro, -1

机译：前列腺特异的膜抗原特异的转化性生长因子-β不敏感的遗传靶向CD8 + T细胞源自转移性去势抵抗性疾病患者的抗人前列腺癌功效
7. 344: Off-the-Shelf Tumor Immunotherapy with Genetically Enhanced Allogeneic T-Cell Precursors [O] . Zakrzewski J.L., Suh D., Markley J.C., 2008

机译：344：采用基因增强的同种异体T细胞前体的现成肿瘤免疫疗法
8. Immunotherapy of Prostate Cancer with Genetically Enhanced Tumor- Specific T Cell Precursors [R] . Brink, M. V. 2010

机译：用遗传性增强的肿瘤特异性T细胞前体免疫治疗前列腺癌

Immunotherapy of Prostate Cancer With Genetically Enhanced Tumor- Specific T-Cell Precursors

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