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首页> 美国政府科技报告 >A Bioassay of the Prominent Humoral Agents Involved in Enditoxin Shock
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A Bioassay of the Prominent Humoral Agents Involved in Enditoxin Shock

机译：一种涉及内毒素休克的突出体液因子的生物测定

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This report defines the release of neurohumoral substances into the circulation after the intravenous administration of a lethal dose of E. coli endotoxin. An isolated saphenous vein in circuit with either an intact or a surgically eviscerated dog allowed the measurement of vessel-tension changes and afforded a continuous bioassay of the existing neurohumoral balance; blocking agents were used to define the agent that was active at any one given time. Histamine, or a similar compound, was active in the first phase of shock with catecholamines playing the predominant role during the second hypotensive phase. A parasympathetic-like response (third phase), causing bradycardia and hypotension, was also noted. (Author)

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