Role of Fetuin-A in Breast Tumor Cell Growth

机译：胎球蛋白-a在乳腺肿瘤细胞生长中的作用

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In this final report we report that we successfully completed task number 1, after doing additional experiments requested by the reviewers. The manuscript is presently under editorial review in the American Journal of Pathology. In the past year we have concentrated mainly on Task No. 2. The most significant reportable outcome of this task is that we have now removed doubts regarding the authenticity of fetuin-A as adhesion and growth signaling molecule. The purification protocol we have developed can purify fetuin-A to 100% purity. More importantly we have shown that human fetuin-A (ahsg) behaves exactly like its bovine counterpart. We have shown that in addition to mediating the activation of PI3 kinase/Akt, fetuin-A at high concentrations can also activate MAP kinases. We have also shown that in regular tissue culture, fetuin-A could be more relevant for cellular attachment than integrins. Fetuin- A is also actively internalized by the tumor cells but the significance of this internalization is presently unclear.

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Ochieng, J.;
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年度 2010
页码 1-13
总页数 13
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Breast cancer ; Cells(Biology) ; Antigens ; Mammary glands ; Phosphorus transferases ; Neoplasms ; Histopathology;

机译：乳腺癌;细胞（生物学）;抗原;乳腺;磷转移酶;肿瘤;组织病理学;

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1. Fetuin-A (α2HS-Glycoprotein) Is a Major Serum Adhesive Protein That Mediates Growth Signaling in Breast Tumor Cells [J] . Amos Sakwe, Rainelli Koumangoye, Shawn Goodwin, The Journal of biological chemistry . 2010,第53期

机译：Fetuin-A（α2HS-糖蛋白）是一种主要的血清粘合剂蛋白，其在乳腺肿瘤细胞中介导生长信号
2. Lack of Fetuin-A ([alpha]2-HS-Glycoprotein) Reduces Mammary Tumor Incidence and Prolongs Tumor Latency via the Transforming Growth Factor-[beta] Signaling Pathway in a Mouse Model of Breast Cancer [J] . Bobby Guillory, Amos M. Sakwe, Margret Saria, The American journal of pathology. . 2010,第5期

机译：在乳腺癌小鼠模型中，缺乏胎球蛋白-A（α2-HS-糖蛋白）通过转化生长因子-β信号传导途径降低了乳腺肿瘤的发生率并延长了肿瘤潜伏期。
3. Lack of fetuin-A (alpha2-HS-glycoprotein) reduces mammary tumor incidence and prolongs tumor latency via the transforming growth factor-beta signaling pathway in a mouse model of breast cancer. [J] . Guillory B, Sakwe AM, Saria M, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2010,第5期

机译：缺乏Fetuin-A（α2-HS-糖蛋白）可通过在乳腺癌的小鼠模型中通过转化生长因子-β信号传导途径延长乳腺肿瘤发病率并延长肿瘤潜伏期。
4. IR spectroscopy and IR microscopy of human breast tumors xenografted breast tumors and breast tumor cell lines [C] . Heinz Fabian, Max-Delbrueck-Ctr. for Molecular Medicine, Berlin, Infrared Spectroscopy: New Tool in Medicine . 1998

机译：人乳腺肿瘤异种移植乳腺肿瘤和乳腺肿瘤细胞系的红外光谱和红外显微镜
5. Characterization of Mechanism(s) of Anti-Tumor Growth Exerted by Eosinophilic Cell Lines on Breast Tumor Cell Lines [D] . Laniyan, Ibrahim 2010

机译：嗜酸性细胞系对乳腺癌细胞系的抗肿瘤生长机制的表征
6. Fetuin-A (α2HS-Glycoprotein) Is a Major Serum Adhesive Protein That Mediates Growth Signaling in Breast Tumor Cells [O] . Amos M. Sakwe, Rainelli Koumangoye, Shawn J. Goodwin, 2010

机译：Fetuin-A（α2HS-糖蛋白）是一种主要的血清粘附蛋白可介导乳腺癌细胞中的生长信号。
7. Fetuin-A (α2HS-Glycoprotein) Is a Major Serum Adhesive Protein That Mediates Growth Signaling in Breast Tumor Cells* [O] . Sakwe, Amos M., Koumangoye, Rainelli, Goodwin, Shawn J., 2010

机译：Fetuin-A（α2HS-糖蛋白）是一种主要的血清粘附蛋白，可介导乳腺癌细胞中的生长信号*

Role of Fetuin-A in Breast Tumor Cell Growth

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