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Evaluation of Extracellular Endosulfatase HSULF-2 in Breast Cancer Cell WNT Signaling and Its Inhibition by a Sulfate Ester Derivative of Synthetic Antioxidant.

机译：细胞外内硫素酶HsULF-2在乳腺癌细胞WNT信号转导中的应用及其对合成抗氧化剂硫酸酯衍生物的抑制作用。

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The research results we obtained in this Army Concept grant include the following novel findings. (A) We showed that 2,4- disulfonyl-phenyl-tert- butylnitrone (2,4-SPBN) acts as a weak inhibitor of the enzymatic activity of the extracellular endosulfatase Sulf2 when the enzyme is acting as an aryl sulfatase on the substrate 4-methyllumbelliferyl-O-sulfate (4-MUS) and that 2,4- SPBN was much more effective enzyme inhibitor when Sulf2 acts upon its natural substrate the 6-O-sulfate ester of heparin sulfate. (B) We also made the novel observation that Sulf2 activity was inactivated by hydrogen peroxide. (C) We also showed that the phenyl sulfonyl anti-cancer agent suramin very potently inhibited Sulf2 enzymatic activity. (D) Utilizing a Balb/c nude mouse model we showed that tumor growth of MCF-7 human breast cancer cells was significantly suppressed by administering 2,4-SPBN in the drinking water at 250 mg/kg at 35 days when experiments had to be stopped. These novel observations help us understand the anti-cancer activity of 2,4-SPBN and the potential role of Sulf2 inhibitors as anti-cancer agents and the potential for novel phenyl-sulfonyl agents as possible breast cancer therapeutics.

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作者
Floyd, R. A.;
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年度 2010
页码 1-16
总页数 16
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Breast cancer; Aryl radicals; Cells(Biology); Drinking water; Enzyme inhibitors; Heparin; Neoplasms; Peroxides; Sulfates;

机译：乳腺癌;芳基;细胞（生物学）;饮用水;酶抑制剂;肝素;肿瘤;过氧化物;硫酸盐;

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1. 三氯生对离体鹅尾臀腺和人乳腺癌细胞脂肪酸合成酶的抑制作用 [J] . 王映强, 赖炳森, 等癌症（英文版） . 2003,第003期
2. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88. [J] . Hossain MM, Hosono Fukao T, Tang Glycobiology. . 2010,第2期

机译：直接检测细胞外硫酸乙酰肝素上的HSulf-1和HSulf-2活性及其被PI-88抑制。
3. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88 [J] . Kenji Uchimura Glycobiology . 2010,第2期

机译：直接检测细胞外硫酸乙酰肝素上的HSulf-1和HSulf-2活性及其对PI-88的抑制作用
4. Specific sulfation patterns in heparan sulfate promote a proinvasive phenotype of breast cancer cells via upregulation of Wnt and MAPK signaling [J] . Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association . 2013,第3期

机译：硫酸乙酰肝素中的特定硫酸化模式通过Wnt和MAPK信号转导上调促进乳腺癌细胞的侵袭性表型
5. Nanoparticles Coated with Frizzled7 Antibodies Enable Multivalent Binding for Enhanced Wnt Signaling Inhibition in Triple-Negative Breast Cancer [C] . Rachel S. Riley, Emily S. Day Society for Biomaterials annual meeting and exposition . 2018

机译：纳米颗粒涂有Frizzled7抗体使三价乳腺癌中增强Wnt信号抑制的多价结合。
6. Therapeutic ck2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells. [D] . Gray, Gary Kenneth. 2014

机译：ck2的治疗抑制作用减弱了多种生存信号通路，并降低了人乳腺癌细胞的细胞活力。
7. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88 [O] . Md Motarab Hossain, Tomomi Hosono-Fukao, Renhong Tang, -1

机译：直接检测细胞外硫酸乙酰肝素上的HSulf-1和HSulf-2活性及其对PI-88的抑制作用
8. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88 [O] . Hossain, Md Motarab, Hosono-Fukao, Tomomi, Tang, Renhong, 2009

机译：直接检测细胞外硫酸乙酰肝素上的HSulf-1和HSulf-2活性及其对PI-88的抑制作用

Evaluation of Extracellular Endosulfatase HSULF-2 in Breast Cancer Cell WNT Signaling and Its Inhibition by a Sulfate Ester Derivative of Synthetic Antioxidant.

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