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Determining the Molecular and Genetic Basis for Diabetes in Navy Bottlenose Dolphins (Tursiops truncatus).

机译：确定海军宽吻海豚（Tursiops truncatus）糖尿病的分子和遗传基础。

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CREB-ZF functions as a transcriptional represser, at least in terms of its effects on gluconeogenic genes. Efforts are underway to determine whether CREB-ZF directly interferes with activation of the cAMP-responsive factor CREB or the CRTC family of CREB coactivators. CREB-ZF has been reported to modulate the unfolded protein response (UPR) although the underlying mechanism is unclear. Because it contains a leucine zipper DNA binding domain, CREB-ZF would be expected to compete for binding to CREB binding sites. We will test whether CREB-ZF displaces CREB and CRTC2 from gluconeogenic promoters and thereby reduces hepatic glucose production.

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作者
Montminy, M. R.;
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年度 2015
页码 1-11
总页数 11
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Diabetes; Dolphins(mammals); Transcription(genetics); Deoxyribonucleic acids; Gene expression; Genes; Glucose; Luciferase; Proteins; Receptor sites(physiology); Creb zf; Fasting; Gluconeogenesis; Transcriptional repression; Upr(unfolded protein response);

机译：糖尿病;海豚（哺乳动物）;转录（遗传学）;脱氧核糖核酸;基因表达;基因;葡萄糖;荧光素酶;蛋白质;受体位点（生理学）; Creb zf;禁食;糖原异生;转录抑制; Upr（未折叠蛋白反应）;

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专利

1. Evaluation of annual survival and mortality rates and longevity of bottlenose dolphins (Tursiops truncatus) at the United States Navy Marine Mammal Program from 2004 through 2013 [J] . Venn-Watson Stephanie K., Jensen Eric D., Smith Cynthia R., Journal of the American Veterinary Medical Association . 2015,第8期

机译：2004年至2013年美国海军海洋哺乳动物计划对宽吻海豚（Tursiops truncatus）的年生存率和死亡率以及寿命的评估
2. Evaluation of population health among bottlenose dolphins (Tursiops truncatus) at the United States Navy Marine Mammal Program. [J] . Venn-Watson S. K., Jensen E. D., Ridgway S. H. Journal of the American Veterinary Medical Association . 2011,第3期

机译：在美国海军海洋哺乳动物计划中评估宽吻海豚（ Tursiops truncatus ）中的种群健康。
3. Beyond genetic differences: epigenetic variation in common bottlenose dolphins Tursiops truncatus from contrasting marine ecosystems [J] . Correa Tatsch Ana Carolina, Proietti Maira Carneiro, Zanini Rebeca, Marine ecology progress series . 2021,第Auga5期

机译：除了遗传差异之外：常见瓶颈海豚Tursiops truncatus从造影海洋生态系统的表观遗传变异
4. Predictive models for abundance estimation and distribution maps of the striped dolphin Stenella coeruleoalba and the bottlenose dolphin Tursiops truncatus in the Northern Ionian Sea (North-eastern Central Mediterranean) [C] . Renò V., Fanizza C., Dimauro G., Conference on Multimodal Sensing: Technologies and Applications . 2019

机译：北极海北极海（东北部地中海东北部地中海）条纹海豚史内特Coeruleoalba和瓶颈海豚Tursiops truncatus的预测模型
5. Using comparative metagenomics to determine the role of Atlantic bottlenose dolphins (Tursiops truncatus) as sentinels for human respiratory health. [D] . Stellick Seepaulsingh, Sarah H. 2014

机译：使用比较宏基因组学来确定大西洋宽吻海豚（Tursiops truncatus）作为人类呼吸系统健康的前哨作用。
6. Genetic isolation of a now extinct population of bottlenose dolphins (Tursiops truncatus) [O] . Courtney Nichols, Jerry Herman, Oscar E Gaggiotti, 2007

机译：现已灭绝的宽吻海豚种群的遗传分离（Tursiops truncatus）
7. Genetic bottleneck and founder effect signatures in a captive population of common bottlenose dolphins Tursiops truncatus (Montagu 1821) in Mexico [O] . Monica Améndola-Pimenta, Miriam Camelo-Marrufo, Jesús Alejandro Zamora-Briseño, 2018

机译：遗传瓶颈和创始人效应群落在墨西哥的常见瓶颈海豚Tursioops truncatus（Montagu 1821）的俘虏群体中的签名

Determining the Molecular and Genetic Basis for Diabetes in Navy Bottlenose Dolphins (Tursiops truncatus).

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