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Development of Single-Molecule DNA Sequencing Platform Based on Single-Molecule Electrical Conductance.

机译：基于单分子电导的单分子DNa测序平台的研制。

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The significant findings in this report come from the in vitro, ex vivo, and in vivo evidence data which suggests that gold nanoparticles (GNPs) activate B-cells and enhance immunoglobulin G secretion. GNP treatment upregulates blimp1, downregulates pax5, and enhances downstream IgG secretion. The enhancement is size dependent and time dependent. GNPs ranging from 2 to 12 nm had the maximum stimulatory activity for the production of antibody. This is the first time that specific signal transduction pathway has been unambiguously identified and assigned to nanoparticles in a size-dependent manner. We have thus established the link between physical dimension and biological response at molecular level. In the future, it is possible to imitate this physical stimulation through "nonphysical" manipulation, such as genetic control. In particular, the interaction of immune system and nanoparticles could be manipulated through genetic control. The instant advantage is to establish stable and high affinity bionano interface in the fabrication of the unique molecular electronic device, the protein transistor. New research questions which this research has raised include, how does the immune system sense the size of nanoparticles? Are there size-specific genes?

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作者
Huang, G.;
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年度 2015
页码 1-25
总页数 25
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Biochemistry; Gold; Nanoparticles; Antibodies; Deoxyribonucleic acids; Electrical conductivity; Fabrication; Genes; Genetics; Immunoglobulins; In vitro analysis; In vivo analysis; Interfaces; Molecular electronics; Nanotechnology; Optimization; Proteins; Receptor sites(physiology); Response(biology); Secretion; Transducers; Transistors; Nanobiotechnology; Signal transduction pathways; Gnps(gold nanoparticles); Pe61102f;

机译：生物化学;金;纳米粒子;抗体;脱氧核糖核酸;电导率;制造;基因;遗传学;免疫球蛋白;体外分析;体内分析;界面;分子电子学;纳米技术;优化;蛋白质;受体位点（生理学）;反应（生物学））;分泌;换能器;晶体管;纳米生物技术;信号转导途径; Gnps（金纳米粒子）; pe61102f;

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专利

1. Single-Molecule Electrical Random Resequencing of DNA and RNA [J] . Takahito Ohshiro, Kazuki Matsubara, Makusu Tsutsui, Scientific reports. . 2012,第1期

机译：DNA和RNA的单分子电随机重测序
2. Continuous base identification for single-molecule nanopore DNA sequencing [J] . Clarke J, Wu HC, Jayasinghe L, Nature nanotechnology . 2009,第4期

机译：连续碱基鉴定，用于单分子纳米孔DNA测序
3. Single-molecule, motion-based DNA sequencing using RNA polymerase. [J] . Greenleaf WJ, Block SM Science . 2006,第5788期

机译：使用RNA聚合酶的单分子，基于运动的DNA测序。
4. Rapid sequencing of DNA based on single-molecule detection [C] . Steven A. Soper, Los Alamos National Lab., Baton Rouge, Optical Methods for Ultrasensitive Detection and Analysis: Techniques and Applications . 1991

机译：基于单分子检测的DNA快速测序
5. Using synthetic nanopores for single-molecule analyses: Detecting SNPs, trapping DNA molecules, and the prospects for sequencing DNA. [D] . Dimitrov, Valentin V. 2009

机译：使用合成的纳米孔进行单分子分析：检测SNP，捕获DNA分子以及DNA测序的前景。
6. Single-Molecule Electrical Random Resequencing of DNA and RNA [O] . Takahito Ohshiro, Kazuki Matsubara, Makusu Tsutsui, -1

机译：DNA和RNA的单分子电随机重测序
7. Analytical Currents: STED microscopy illuminates vesicle fate Imaging of the oxidant peroxynitrite in living cells Solid immersion lenses made from PDMS Molecular sorting in microfluidic devices DNA sequencing on a chip Single-molecule binding assay in femtoliter arrays Simple derivatization of glycopeptides for MALDI Direct electrical detection of DNA synthesis [O] . 2006

机译：分析电流：STED显微镜照亮囊泡命运活细胞氧化剂过氧硝酸盐的成像由PDMS制成的固体浸没镜片微流体装置中的分子分选芯片上的DNA测序 Femtoliter阵列中的单分子结合测定马尔迪糖肽的简单衍生化直接电气检测DNA合成

Development of Single-Molecule DNA Sequencing Platform Based on Single-Molecule Electrical Conductance.

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