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Connective Tissue Growth Factor (CTGF) as a Regulator of Lactogenic Differentiation

机译：结缔组织生长因子（CTGF）作为乳酸分化的调节剂

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The degree of differentiation of mammary epithelial cells is dependent on their response to basement membrane and stromal protein-induced signals. Connective Tissue Growth Factor (CTGF/CCN2), a known stromal mediator, is highly upregulated by dexamethasone and is required for the lactogenic differentiation of mouse mammary epithelial cells. Using a Tet-off system to overexpress CTGF/CCN2 in the HC11 cell background, we found that its elevated expression enhanced multiple markers of lactogenic differentiation, including beta-casein transcription, mammosphere formation, and stabilization of Stat5 activity. Elevated levels of CTGF/CCN2 partially abrogated the requirement of matrix proteins for the transcription of beta-casein, suggesting that CTGF/CCN2 contributes to lactogenic differentiation through a regulation of cell:matrix adhesion.

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作者
Morrison, B. L.;
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年度 2009
页码 1-178
总页数 178
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Connective tissue ; Membranes(Biology) ; Theses ; Mammary glands ; Growth(Physiology) ; Epithelium ; Cells(Biology);

机译：结缔组织;膜（生物学）;论文;乳腺;生长（生理学）;上皮;细胞（生物学）;

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专利

1. Connective Tissue Growth Factor (CTGF/CCN2) enhances lactogenic differentiation of mammary epithelial cells via integrin-mediated cell adhesion [J] . Bethanie L Morrison, Cynthia C Jose, Mary L Cutler BMC Cell Biology . 2010,第1期

机译：结缔组织生长因子（CTGF / CCN2）通过整合素介导的细胞黏附增强乳腺上皮细胞的生乳分化
2. Essential role of connective tissue growth factor (CTGF) in transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from Graves’ orbital fibroblasts [J] . Chieh-Chih Tsai, Shi-Bei Wu, Hui-Chuan Kau, Scientific reports. . 2018,第1期

机译：结缔组织生长因子（CTGF）在转化生长因子-β1（TGF-β1）中的基本作用 - 诱导坟墓眶纤维细胞的肌纤维细胞转化率
3. Effects of connective tissue growth factor (CTGF/CCN2) on condylar chondrocyte proliferation, migration, maturation, differentiation and signalling pathway [J] . Xin Xing, Zhi Li, Zili Yu, Biochemical and Biophysical Research Communications . 2018,第1期

机译：结缔组织生长因子（CTGF / CCN2）对髁突软骨细胞增殖，迁移，成熟，分化和信号通路的影响
4. Connective tissue growth factor (CTGF/CCN2) and Connexin-43 (0x43) expression are upregulated in human adipose-derived stromal cells (hASCs) over the course of osteogenic differentiation [C] . Panetta NJ, Gupta DM, Gupta A, International Society of Craniofacial Surgery International Congress . 2009

机译：在骨质发生分化的过程中，在人脂肪衍生的基质细胞（HASC）中，将结缔组织生长因子（CTGF / CCN2）和Connexin-43（0x43）表达上调
5. Src kinase signaling regulates connective tissue growth factor (CTGF/CCN2) induction by transforming growth factor-beta 1 (TGF-beta1) in osteoblasts. [D] . Zhang, Xuemei. 2010

机译：Src激酶信号传导通过转化成骨细胞中的生长因子-beta 1（TGF-beta1）来调节结缔组织生长因子（CTGF / CCN2）的诱导。
6. Connective Tissue Growth Factor (CTGF/CCN2) enhances lactogenic differentiation of mammary epithelial cells via integrin-mediated cell adhesion [O] . Bethanie L Morrison, Cynthia C Jose, Mary Lou Cutler 2001

机译：结缔组织生长因子（CTGF / CCN2）通过整合素介导的细胞粘附增强乳腺上皮细胞的生乳分化
7. Connective Tissue Growth Factor (CTGF/CCN2) enhances lactogenic differentiation of mammary epithelial cells via integrin-mediated cell adhesion [O] . Bethanie L Morrison, Cynthia C Jose, Mary Cutler 2012

机译：结缔组织生长因子（CTGF / CCN2）通过整合素介导的细胞粘附增强乳腺上皮细胞的生乳分化

Connective Tissue Growth Factor (CTGF) as a Regulator of Lactogenic Differentiation

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