• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Molecular Biology and Prevention of Endometrial Cancer
【24h】

Molecular Biology and Prevention of Endometrial Cancer

机译：分子生物学与子宫内膜癌的预防

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To increase our understanding of the molecular aberrations associated with endometrial carcinogenesis and the biologic mechanisms underlying the protective effect of oral contraceptive (OC) therapy. Methods: (1) Oligonucleotide microarray analysis was performed on a panel of endometrial cancers. (2) A subset of adenocarcinoma cases from the International DES Registry (IDESR) was analyzed for MSI (3) A case-control study of the CASH database was performed to evaluate the relationship between progestin potency and endometrial cancer risk. (4) An analysis of endometrium samples from cymologous macaques that were exposed to long term progestins was performed. (5) A clinical trial comparing progestin versus placebo is underway that will facilitate investigation of the effects of progestin exposure on the endometrial lining. Results: (1) Different histological types of endometrial cancer have unique genomic expression patterns. (2) The poor quality DNA from the majority of IDESR samples prohibited an adequate analysis of the case set. (3) A case-control study has suggested higher progestin- potency OCs may be more protective than lower progestin potency OCs among women with a larger body habitus. (4) Macaque studies have suggested that induction of apoptosis may be a mechanism underlying the chemoprotective effects of progestin on the endometrium. (5) Regulatory hurdles have resulted in delays in initiation of the clinical trial which is now currently underway.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号