Role of ABC Proteins in Drug Resistant Breast Cancer Cells

机译：aBC蛋白在耐药乳腺癌细胞中的作用

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This predoctoral training grant, supported by the Department of Defense Breast Cancer Research Program (BCRP) of the Office of the Congressionally Directed Medical Research Programs (CDMRP), aims to study the possible role of membrane transporters in pleitropic drug resistance, using a combination of molecular biological, biochemical, and biophysical methods. The third year of funding was spent in further characterization of the Plasmodium falciparum Chloroquine Transporter (PfCRT), a member of a drug/metabolite transporter superfamily. Data from the previous year provided proof of the protein's direct interaction with its drug substrate. I have subsequently employed a methodology commonly applied to drug resistance proteins (such as human P-glycoprotein) and defined the drug binding site through mass spectrometry. This report summarizes work conducted from March 2008 through June 2008, when my work on this project ceased due to graduation. A request for a change of PI for this award has been submitted and is pending review.

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作者
Pleeter, P.; Lekostaj, J. K.;
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年度 2009
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Cells(Biology) ; Mass spectrometry ; Resistance(Biology) ; Physicians ; Drugs ; Plasmodium falciparum ; Grants ; Metabolites ; Biophysics ; Chloroquine ; Proteins ; Interactions ; Cargo vehicles;

机译：细胞（生物学）;质谱;抗性（生物学）;内科医生;药物;恶性疟原虫;药物;代谢物;生物物理学;氯喹;蛋白质;相互作用;货运车辆;

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1. MiR-181a enhances drug sensitivity in mitoxantone-resistant breast cancer cells by targeting breast cancer resistance protein (BCRP/ABCG2) [J] . JiaoX., ZhaoL., MaM., Breast cancer research and treatment. . 2013,第3期

机译：MiR-181a通过靶向乳腺癌抗性蛋白（BCRP / ABCG2）来增强抗米托蒽醌的乳腺癌细胞的药物敏感性
2. Forced Expression of Heat Shock Protein 27 (Hsp27) Reverses P-Glycoprotein (ABCB1)-mediated Drug Efflux and MDR1 Gene Expression in Adriamycin-resistant Human Breast Cancer Cells [J] . Ragu Kanagasabai, Karthikeyan Krishnamurthy, Lawrence Druhan, The Journal of biological chemistry . 2011,第38期

机译：热休克蛋白27（HSP27）的强制表达逆转在亚霉素抗性人乳腺癌细胞中的p-糖蛋白（ABCB1）介导的药物流出和MDR1基因表达
3. Unexpected Lower Expression of Oncoprotein Gankyrin in Drug Resistant ABCG2 Overexpressing Breast Cancer Cell Lines [J] . Maryam Taheri, Khadijeh Jamialahmadi, Fatemeh Kalalinia Asian Pacific Journal of Cancer Prevention . 2017,第12期

机译：耐药蛋白ABCG2过表达的乳腺癌细胞系中癌蛋白gankyrin的意外降低表达
4. Phosphoproteomic Analysis of Drug-Resistant Gastric Cancer Cells: Running title - MRM-Based Quantitative Analysis of Phosphosignaling Proteins with Response to Anti-IGF1R Antibody Drug Treatment [C] . Yong Yook Lee, Byoung-Kyu Cho, Minjueng Kang, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：抗药性胃癌细胞的磷蛋白蛋白质分析：抗IGF1R抗体药物治疗抗IGF1R抗体药物治疗的磷酸术 - MRM的定量分析
5. A comparative proteomic analysis of mitochondrial proteins from drug susceptible and drug resistant human MCF-7 breast cancer cells. [D] . Strong, Rachael F. 2005

机译：药物敏感性和耐药性人MCF-7乳腺癌细胞线粒体蛋白质的比较蛋白质组学分析。
6. Forced Expression of Heat Shock Protein 27 (Hsp27) Reverses P-Glycoprotein (ABCB1)-mediated Drug Efflux and MDR1 Gene Expression in Adriamycin-resistant Human Breast Cancer Cells [O] . Ragu Kanagasabai, Karthikeyan Krishnamurthy, Lawrence J. Druhan, 2011

机译：热休克蛋白27（Hsp27）的强制表达逆转P-糖蛋白（ABCB1）介导的药物外流和抗阿霉素的人乳腺癌细胞中的MDR1基因表达。
7. The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: Implications for therapy of drug resistant breast cancers [O] . Alessandra Cappellini, Francesca Chiarini, Andrea Ognibene, 2009

机译：细胞周期蛋白依赖性激酶抑制剂Roscovitine和核苷类似糖蛋白诱导肠脑-3缺乏乳腺癌细胞中凋亡，与胱天蛋白酶介导的p-糖蛋白切割裂解：对耐药乳腺癌治疗的影响

Role of ABC Proteins in Drug Resistant Breast Cancer Cells

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