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首页> 美国政府科技报告 >Randomized Placebo-Controlled Trial of Citalopram for Anxiety Disorders Following Traumatic Brain Injury
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Randomized Placebo-Controlled Trial of Citalopram for Anxiety Disorders Following Traumatic Brain Injury

机译：西酞普兰治疗创伤性脑损伤后焦虑障碍的随机安慰剂对照试验

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The overarching goal of this project was to study the effects of a serotonin reuptake inhibitor (SRI), citalopram, for the treatment of anxiety experienced by individuals after traumatic brain injury (TBI). Specifically, this project sought to treat individuals who meet criteria for DSM-IV diagnosis of Anxiety Disorder Due to a General Medical Condition, within 3 to 24 months of TBI. A randomized placebo controlled design with 1-year follow-up was utilize to evaluate the effectiveness of citalopram in alleviating significant anxiety symptoms that cause significant distress and can lead to medical retirement active duty soldiers. 19 participants (8 Citalopram and 11 placebo) completed the study. The study did not find significant differences in the anxiety measures between the Citalopram and placebo groups at the week 12 assessment. However, the Citalopram group had lower scores STAI and HAM-A than the placebo group. The lack of statistical significance may have been due in part to the small sample size. The small sample size resulted from difficulties identifying service members who were able to participate in this study as a result of war injuries from OIF/OEF.

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