首页> 美国政府科技报告 >Effect of COX-2 (PGE2) and IL-6 on Prostate Cancer Bone Metastases; Final rept. 3 Jan 2005-2 Jan 2008

【24h】

Effect of COX-2 (PGE2) and IL-6 on Prostate Cancer Bone Metastases; Final rept. 3 Jan 2005-2 Jan 2008

机译：COX-2（pGE2）和IL-6对前列腺癌骨转移的影响;最终的评论。 2005年1月3日至2008年1月3日

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

We hypothesized that (1) prostate cancer cells that express high levels of cyclooxygenase-2 (COX-2) and prostaglandin E2(PGE2) display enhanced bone targeting and (2) the level of expression of COX-2 and PGE2 in established bone metastases determines the overall bone response, with lower vs. higher levels inducing osteoblastic vs. osteolytic responses, respectively. We utilized two human prostate cancer cell lines (MDA-PCa-2B that expresses low levels of COX-2 and PGE2 and produces osteoblastic lesions vs. PC-3 that expresses high levels COX-2/PGE2 and induces osteolytic mets). We demonstrated that (1) low levels of PGE2 stimulate preosteoblast cell growth, differentiation and Wnt signaling (2) Forced overexpression of COX-2 in MDA-PCa- 2b cells induces the Wnt antagonist DKK-1 (3) PGE2 addition to PC-3 cells stimulates Dkk-1 (4) Forced overexpression of COX-2 in MDA-PCa-2B cells inhibits preosteoblastic cell growth in co-culture and, finally, (5) Treatment with a COX-2 inhibitor reduced PC-3 metastatic lesions in vivo after intracardiac inoculation. Over the next several weeks we will analyze bone metastatic lesions to determine overall bone response in vivo from the PC-3 experiments and from tibia of mice inoculated with wild-type vs. COX-2 overexpressing MDA-PCa-2b cells. These studies confirmed our hypothesis that levels of COX-2/PGE2 expression in prostate cancer cells modulates both bone targeting and bone response.

著录项

作者
Levine, A. C.;
展开▼
作者单位

展开▼
年度 2008
页码 p.1-35
总页数 35
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Prostate cancer; Lesions; Metastasis; Cells(Biology); Bones;

机译：前列腺癌;病变;转移;细胞（生物学）;骨骼;

相似文献

外文文献
中文文献
专利

1. Reply from Authors re: Bertrand Tombal. Zometa european study (ZEUS): Another failed crusade for the holy grail of prostate cancer bone metastases prevention? Eur Urol 2015;67:492-4: ZEUS: the quest for the holy grail of prostate cancer bone metastases prevention continues [J] . Anup Patel, Manfred Wirth Indian heart journal . 2015,第3期

机译：作者回复Re：Bertrand Tombal。 Zometa欧洲学习（Zeus）：另一种失败的前列腺癌骨转移预防爪索的十字军划线？ 2015年欧元乌尔尔2015; 67：492-4：宙斯：寻求前列腺癌骨转移的圣杯继续预防
2. Re: Frank-Jan H. Drost, Daniel Osses, Daan Nieboer, et al. Prostate Magnetic Resonance Imaging, with or Without Magnetic Resonance Imaging-targeted Biopsy, and Systematic Biopsy for Detecting Prostate Cancer: A Cochrane Systematic Review and Meta-analysis. Eur Urol 2020;77:78-94 Are Targeted Prostate Biopsies Enough in Men with a Previous Negative Biopsy? [J] . European urology . 2020,第5期

机译：Re：Frank-Jan H. Drost，Daniel Osses，Daan Nieboer等。前列腺磁共振成像，有或没有磁共振成像 - 靶向活组织检查，以及用于检测前列腺癌的系统活检：Cochrane系统评论和Meta分析。 EUR UROL 2020; 77：78-94是针对前列腺活组织检查足够的男性，以前的负面活检？
3. Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration-resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: a double-blind, placebo-controlled, randomized Phase II trial [J] . Nicholas D. James, Armelle Caty, Heather Payne, BJU International . 2010,第7期

机译：特定的内皮素A受体拮抗剂Zibotentan（ZD4054）在无痛或轻度疼痛症状的转移性去势抵抗性前列腺癌和骨转移患者中的最终安全性和有效性分析：双盲，安慰剂对照，随机分期二审
4. A Retrospective Study of 172 Neurological Patients Presented to the Gyeongsang National University Animal Medical Center; From Jan. 2008 to Jan. 2012 [C] . Joon-Hyeok Jeon, Byeong-Teck Kang, Chang-Moo Ji, FutureTech 2012;FTRA international conference on future information technology;International workshop on biological IT-system convergence;BITSC 2012;International workshop on computer images and its applications;CIA 2012;International workshop on mobile platform, computing and applications;MPCA 2012;International workshop on social computing, network, and services;SocialComNet 2012;Internaional symposium on digital forensics and information security;DFIS 2012;International workshop on IT service cloud computing;ISCC 2012;International conference on mobile, ubiquitous and intelligent computing;MUSIC 2012 . 2012

机译：庆尚国立大学动物医学中心对172名神经系统疾病患者的回顾性研究；从2008年1月到2012年1月
5. Effect of phytochemicals on growth and prostaglandin E2 (PGE2) synthesis in PC-3 cells, a prostate cancer cell line [D] . Burr, Andrew 2011

机译：植物化学物质对前列腺癌细胞PC-3细胞生长和前列腺素E2（PGE2）合成的影响
6. In regard to Tran A Zhang J Woods K Yu V Nguyen D Gustafson G Rosen L Sheng K. Treatment planning comparison of IMPT VMAT and 4π radiotherapy for prostate cases. Radiation oncology. 2017 Jan 11; 12(1):10 [O] . Biplab Sarkar 2018

机译：关于 Tran AZhang JWoods KYu VNguyen DGustafson GRosen LShengK。IMPTVMAT和4π放射疗法对前列腺病例的治疗计划比较。放射肿瘤学。 2017一月11; 12（1）：10
7. Qualidade pós-colheita de frutos de butiá em função do estádio de maturação na colheita e do manejo da temperatura: v.38, n.1, p.46-53, jan-fev, 2008 Postharvest quality of jelly palm fruits as a result of maturity stage at harvest and temperature management: v.38, n.1, p.46-53, jan-fev, 2008 [O] . 2008

机译：Qualidadepós-colheita de frutos debutiáemfunçãodoestádiodhematuraçãonacolheita e do manejo da Temperatura：v.38，n.1，p.46-53，jan-fev，2008采后果冻果实的采后品质收获和温度管理的成熟阶段：v.38，n.1，p.46-53，jan-fev，2008

Effect of COX-2 (PGE2) and IL-6 on Prostate Cancer Bone Metastases; Final rept. 3 Jan 2005-2 Jan 2008

摘要

著录项

相似文献

相关主题

期刊订阅