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Conformational Changes in Small Ligands Upon Tetanus Toxin Binding; Final rept. Apr 2006-May 2008

机译：破伤风毒素结合后小配体的构象变化;最终的评论。 2006年4月至2008年5月

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To understand the processes associated with small synthetic ligands binding large protein surfaces, NMR spectroscopy was used to examine the conformational changes in doxorubicin and lavendustin A upon binding to tetanus toxin. C13 T1 measurements suggested that to a first approximation, the conformational behavior of doxorubicin in solution appears to be a composite of a rigid aromatic ring system, ring librations for its cyclohexane and carbohydrate rings, and segmental motions for the pendant C(O)CH2OH group. trNOESY experiments indicated that both ligands adopt rigid conformations when bound to tetanus toxin and each binds a different site on the toxin surface.

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作者
Henderson, T. J.; Gitti, R. K.;
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年度 2008
页码 p.1-26
总页数 26
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Nuclear magnetic resonance; Ligands; Bacterial toxins; Clostridium tetani; Biological agent detectors; Molecules;

机译：核磁共振;配体;细菌毒素;破伤风梭菌;生物制剂探测器;分子;

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1. Cooperative binding of anti-tetanus toxin monoclonal antibodies: Implications for designing an efficient biclonal preparation to prevent tetanus toxin intoxication [J] . Vaccine . 2018,第26期

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2. Binding and cleavage (BINACLE) assay for the functional in vitro detection of tetanus toxin: applicability as alternative method for the safety testing of tetanus toxoids during vaccine production. [J] . Behrensdorf-Nicol H. A., Bonifas U., Hanschmann K. M., Vaccine . 2013,第52期

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3. The monoclonal antibody 26 raised against tetanus toxoid also recognizes tetanus toxin and β_2-glycoprotein I - its binding properties in vitro and potential applications [J] . ALEKSANDRA B. INIC-KANADA, MARIJANA M. STOJANOVIC, IRENA P. ZIVKOVIC, Journal of the Serbian Chemical Society . 2009,第3期

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4. Fluorescence Emission and Polarization Analyses for Evaluating Binding of Ruthenium Metalloglycocluster to Lectin and Tetanus Toxin C-Fragment [C] . Tomoko Okada, Norihiko Minoura Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications II . 2010

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5. Theoretical binding studies of the clostridial tetanus toxin and the ganglioside GD1b. [D] . Buczko, Ellen Sara. 2002

机译：梭菌破伤风毒素和神经节苷脂GD1b的理论结合研究。
6. Conformational changes of the glucocorticoid receptor ligand binding domain induced by ligand and cofactor binding and the location of cofactor binding sites determined by hydrogen/deuterium exchange mass spectrometry [O] . Lee Frego, Walter Davidson 2006

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Conformational Changes in Small Ligands Upon Tetanus Toxin Binding; Final rept. Apr 2006-May 2008

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