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Genomic and Expression Profiling of Benign and Malignant Nerve Sheath Tumors in Neurofibromatosis Patients

机译：神经纤维瘤病患者良恶性神经鞘瘤的基因组和表达谱分析

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The goal of the study is to identify genes that will serve as molecular markers for progression of neurofibroma to MPNST, and to identify potential therapeutic targets. miRNA expression profiling was performed on 6 cases of MPNSTs, and 7 cases of synovial sarcomas. By using unsupervised hierarchical clustering most tumors were grouped together according to tumor type. Subsequent analyses using Significance Analysis of Microarrays (SAM) identified miRNAs that differentiate between MPNSTs and synovial sarcoma (SS). To develop a cell line model for MPNSTs, global gene expression profiles for cell lines established from 3 primary MPNST and SS tumor tissues was carried out and their expression profiles were compared with other sarcomas. A large tissue microarray (TMA) containing about 200 nerve sheath tumors was used to test for EGFR expression by IHC. Neoplasms in which the majority of samples showed high expression by IHC included MPNST (83% of NF1- associated and 77% of sporadic), 73% of plexiform neurofibroma, 100% diffuse neurofibroma and 93% of SS.

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作者
Rijn, M. V.; Nielsen, T.; Rubin, B.;
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年度 2008
页码 p.1-33
总页数 33
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Tissues(Biology) ; Genes ; Sheaths(Anatomy) ; Patients ; Sarcoma ; Neoplasms ; Peripheral neuropathy ; Genetic mapping ; Therapy ; Clustering ; Cells(Biology) ; Molecules;

机译：组织（生物学）;基因;鞘（解剖学）;患者;肉瘤;肿瘤;周围神经病变;遗传作图;治疗;聚类;细胞（生物学）;分子;

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1. Clinical Genomic Profiling Identifies TYK2 Mutation and Overexpression in Patients With Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors [J] . Hirbe Angela C., Kaushal Madhurima, Sharma Mukesh Kumar, Cancer: A Journal of the American Cancer Society . 2017,第7期

机译：临床基因组分析识别神经纤维瘤病患者1-相关恶性周围神经鞘瘤患者的TYK2突变和过表达
2. PD-L1 Expression and Tumor Infiltrating Lymphocytes in Neurofibromatosis Type 1-Related Benign Tumors and Malignant Peripheral Nerve Sheath Tumors:An Implication for Immune Checkpoint Inhibition Therapy [J] . Jin LIU, Haibo LI, Chengjiang WEI, 中国整形与重建外科(英文) . 2021,第002期

机译：PD-L1 Expression and Tumor Infiltrating Lymphocytes in Neurofibromatosis Type 1-Related Benign Tumors and Malignant Peripheral Nerve Sheath Tumors:An Implication for Immune Checkpoint Inhibition Therapy
3. PD-L1 Expression and Tumor Infiltrating Lymphocytes in Neurofibromatosis Type 1-Related Benign Tumors and Malignant Peripheral Nerve Sheath Tumors: An Implication for Immune Checkpoint Inhibition Therapy [J] . Jin LIU, Haibo LI, Chengjiang WEI, 中国整形与重建外科（英文） . 2021,第002期

机译：神经纤维瘤病1型相关良性肿瘤和恶性周神经鞘瘤中的PD-L1表达和肿瘤浸润淋巴细胞：免疫检查点抑制治疗的含义
4. Laser polarimetry of bioliguids of patients with benign and malignant ovarian tumors [C] . A.P.Peresunko, Suhaiel Saidi ben Mouhamed, SPIE-The International Society for Optical Engineering, International Conference on Correlation Optics . 2004

机译：良性和恶性卵巢肿瘤患者的Bioliguids激光偏振偏振
5. Overexpression of Adenylate Cyclase Isoforms Alters Cell Signaling Pathways in NF1-Null Malignant Peripheral Nerve Sheath Tumors [D] . Hughes, JoAnna. 2018

机译：腺苷酸环化酶同工型的过表达改变了NF1无效恶性周围神经鞘瘤中的细胞信号通路。
6. Clinical Genomic Profiling Identifies TYK2 Mutation and Overexpression in Patients With Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors [O] . Angela C. Hirbe, Madhurima Kaushal, Mukesh Kumar Sharma, -1

机译：临床基因组分析可识别与1型神经纤维瘤病相关的恶性周围神经鞘瘤患者的TYK2突变和过表达
7. Clinical genomic profiling identifiesTYK2mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors [O] . Angela C. Hirbe, Madhurima Kaushal, Mukesh Kumar Sharma, 2016

机译：神经纤维瘤病患者1型相关恶性周围神经鞘瘤患者的临床基因组分析鉴定鉴定和过度表达

Genomic and Expression Profiling of Benign and Malignant Nerve Sheath Tumors in Neurofibromatosis Patients

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