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首页> 美国政府科技报告 >Antibiotic Impregnated Bone Cement for the Treatment of Osteomelitis and Severe Open Fractures: Expanded Options for Surgeons.
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Antibiotic Impregnated Bone Cement for the Treatment of Osteomelitis and Severe Open Fractures: Expanded Options for Surgeons.

机译：抗生素浸渍骨水泥治疗骨质疏松症和严重开放性骨折：外科医生的扩展选择。

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The purpose of this study is to determine the stability, elution profiles and pharmacodynamic properties, in bone cement, of available antibiotic and antifungal medications in an effort to establish a reference of local antibiotic delivery options for treating osteomyelitis and contaminated open fractures with emphasis on viable antibiotic combinations in bone cement for the treatment of multiple drug resistant organisms. The project has successfully developed analytical chemistry methods for description of in vitro antibiotic elution profiles that will be useful when analyzing elution profiles of bone cement containing multiple antibiotics. Early results have successfully identified previously unknown elution potential in bone cement for antibiotics of interest in treating contaminated war wounds and antibiotic resistant infections. In addition, early results contest the historical belief that liquid antibiotics are not compatible with bone cement for purposes of local antibiotic treatment. Analytic chemistry evaluation is currently being completed on the last remaining antibiotic bead sets for individual antibiotics/antifungals and bacterial susceptibility for viable beads is set to begin.

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