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Diet, Physical Activity, and Meditation Intervention in Men With Rising Prostate-Specific Antigen (PSA)

机译:前列腺特异性抗原(psa)升高的男性的饮食,身体活动和冥想干预

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Following surgery or radiation of primary early-stage prostate cancer (PrCA), one in three patients will experience an elevation in serum prostate antigen (PSA) within 10 years. This rises to one in two at 15 years. After such evidence of recurrence, the most common treatment is androgen ablation. We hypothesize that the host-PrCA balance in asymptomatic men with biochemically recurrent PrCA, as reflected by the PSA rise, is favorably affected by an intensive, vegetable-based diet, plus physical activity and mindfulness-based stress reduction. This randomized trial will enroll 60 men with rising PSA levels along with a partner of their choice, half of whom will be randomized to the intervention and half to usual care. The intervention will continue for 3 months, followed by monthly booster sessions for 3 months. Data will be collected on main study outcomes, protocol compliance and adherence, and potential effect modifiers, mediators, and confounders of treatment effect.

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