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Investigation of Neural-Immune Profiling, Transcriptomics and Proteomics and Clinical Tools in Assessing Navy Dolphin Health

机译：研究海军豚豚健康的神经免疫谱，转录组学和蛋白质组学及临床工具的研究

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The United States Navy maintains and employs approximately 70 bottlenose dolphins (Tursiops truncatus), and 25 sea lions (Zalophus californianus). These marine mammals are deployed all over the world and are specially trained to carry out specific missions and to provide Fleet support for the U.S. Navy. Given the value of these animals to the U.S. Navy, health maintenance and disease prevention for these animals are vital to the U.S. Navy Marine Mammal Program's (NMMP) mission and focus. In order to maintain health and disease prevention in these animals it is critical to have the tools to assess health status before, during and after deployment as well as assess efficacy of preventative measures such as vaccines and immunostimulants. This proposal represents the continued development and initial evaluation of three merging technologies that have been focused on advancing our understanding of marine mammal health and disease. These technologies include immune profiling with the advent of dolphin-specific reagents and assays, functional genomics utilizing a dolphin microarray and proteomics. These technologies will continued to be developed, and the technologies will be applied to a subset of archived dolphin samples including both healthy and ill dolphins. Results from these technologies will be analyzed in conjunction with available clinical data to evaluate the potential in determining and assessing dolphin health.

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作者
Romano, T.;
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年度 2007
页码 p.1-8
总页数 8
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Health; Immunity; Dolphins(Mammals); Navy; Stress(Physiology); Proteomics; Animal diseases; Seals(Mammals); Illness; Genes;

机译：健康;免疫;海豚（哺乳动物）;海军;压力（生理学）;蛋白质组学;动物疾病;海豹（哺乳动物）;疾病;基因;

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1. Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. [J] . A Forte, M Finicelli, P De Luca, Journal of cellular and molecular medicine. . 2008,第5aPta2期

机译：手术诱发的颈动脉狭窄中的表达谱：转录组和蛋白质组学的综合研究。
2. Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models [J] . Rogers Simon, Girolami Mark, Kolch Walter, Bioinformatics . 2008,第24期

机译：使用耦合聚类模型研究转录组和蛋白质组表达谱之间的对应关系
3. Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models [J] . Simon Rogers, Mark Girolami, Walter Kolch, Bioinformatics . 2008,第24期

机译：使用耦合聚类模型研究转录组和蛋白质组表达谱之间的对应关系
4. Deep (Phospho)proteomic Profiling with Label-Free Quantification Reveals Critical Gene Products Missed by Transcriptomics in Human Embryonic Stem Cells and Derivatives [C] . Junjie Hou, Ilyas Singec, Laurence M. Brill American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

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5. Single Cell Proteomics Microchip to Profile Immune Function, with Applications in Stem Cell Biology, Translational Disease Mechanism Study and Clinical Therapeutics Monitoring. [D] . Ma, Chao. 2013

机译：单细胞蛋白质组学Microchip可描述免疫功能，并应用于干细胞生物学，转化疾病机制研究和临床治疗学监测。
6. Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation [O] . A Forte, M Finicelli, P De Luca, 2008

机译：手术诱发的颈动脉狭窄中的表达谱：转录组和蛋白质组学的联合研究。
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Investigation of Neural-Immune Profiling, Transcriptomics and Proteomics and Clinical Tools in Assessing Navy Dolphin Health

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