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Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors; Annual Summary Addendum 1 Jul-23 Nov 2007

机译：乳腺癌实体瘤中聚合物给药系统的磁共振成像;年度总结附录2007年7月1日至11月23日

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This study describes the synthesis, characterization and in vitro evaluation of N-(2-hydroxypropyl) methacrylamide(HPMA) copolymer-gadolinium(Gd)- doxorubicin (Dox) conjugates. Copolymers of HPMA were derivatized to incorporate side chains for Gd chelation and Dox conjugation. The conjugates were characterized by their side chain contents T1 relaxivity (r1) stability, and in vitro cytotoxicity. High stability and relaxivity of these conjugates coupled with low toxicity show their potential for monitoring the in vivo fate of HPMA-based drug delivery systems by magnetic resonance imaging techniques.

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作者
Zarabi, B.;
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年度 2007
页码 p.1-25
总页数 25
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Delivery; Drugs; Breast cancer; Magnetic resonance imaging; Stability; Chelation; In vivo analysis; Copolymers; In vitro analysis; Cytotoxins;

机译：分娩;药物;乳腺癌;磁共振成像;稳定性;螯合作用;体内分析;共聚物;体外分析;细胞毒素;

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Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors; Annual Summary Addendum 1 Jul-23 Nov 2007

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