首页> 美国政府科技报告 >Identification of Novel Inverted Terminal Repeat (ITR) Deletions of Human Adenovirus (AD) From Infected Host: Virulent Ads Containing Mixed Populations of Genomic Sequences; Conference paper
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Identification of Novel Inverted Terminal Repeat (ITR) Deletions of Human Adenovirus (AD) From Infected Host: Virulent Ads Containing Mixed Populations of Genomic Sequences; Conference paper

机译:从受感染的宿主中鉴定新的人类腺病毒(aD)的倒置末端重复序列(ITR):含有基因组序列的混合群体的病毒广告;会议论文

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There are a total six different species of human Adenoviruses, designated A through F. All Ads implicated in US military ARD infections are confined within two Ad species, B and E. It was demonstrated and confirmed that the clinical human Ad isolates from natural infections examined in this study carrying random terminal ITR deletions. Whereas, laboratory adapted human Ads including Ad human vaccine strains, such as Wyeth Ad4 and Ad7 strains contain mostly homogeneous and intact ITR sequences. The finding of novel ITR deletions in clinical Ads of natural infections could have significant impacts on the future Ad research and vaccine development.

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