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Hepatocyte Growth Factor and Interleukin-6 in Prostate Cancer Bone Metastasis

机译：肝细胞生长因子和白细胞介素-6在前列腺癌骨转移中的作用

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The hypothesis of this grant proposal is that androgen-ablative therapy paradoxically increases growth factor secretion from bone stromal cells and that this may stimulate the growth of prostate cancer metastases. Based on the presence of androgen receptor regulatory elements in the promoter regions of the Interleukin-6 (IL-6) and hepatocyte growth factor/scatter factor (HGF/SF) genes and the presence of nuclear factor IL-6 binding sites in the promoter of the HGF gene, it is the premise of this project that IL-6 and HGF genes may serve as paradigms of genes that are increased in expression under androgensuppressed conditions. However, initial experiments failed to reveal regulation of HGF and IL-6 by androgen suppression. An analysis of global gene regulation in castrated mice demonstrated that 159 genes were regulated and that Insulin growth Factor Binding Protein-5 demonstrated the most consistent increase in expression. The support provided by the grant fostered the PI's career development to an independent investigator in the field of prostate cancer metastasis to bone. There were several publications supported by the funds from this grant.

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作者
Knudsen, B. S.;
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年度 2006
页码 1-51
总页数 51
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Bones; Metastasis; Prostate cancer; Genes; Cells(Biology); Androgens; Growth(Physiology); Excision;

机译：骨骼;转移;前列腺癌;基因;细胞（生物学）;雄激素;生长（生理学）;切除;

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专利

1. Hepatocyte growth factor and interleukin-6 in combination with prostate volume are possible prostate cancer tumor markers in patients with gray-zone PSA levels [J] . K Nishimura, N Arichi, S Tokugawa, Prostate Cancer and Prostatic Diseases . 2008,第3期

机译：肝细胞生长因子和白细胞介素-6联合前列腺体积可能是灰区PSA水平患者的前列腺癌肿瘤标志物
2. New Insights in the Role of Androgen-to-Estrogen Ratios, Specific Growth Factors and Bone Cell Microenvironment to Potentiate Prostate Cancer Bone Metastasis [J] . Eileen M. McNerney, Sergio A. Onate Nuclear Receptor Research . 2015,第3期

机译：雄激素与雌激素比，特定生长因子和骨细胞微环境在增强前列腺癌骨转移中的作用的新见解
3. Macromolecular dynamic contrast-enhanced (DCE)-MRI detects reduced vascular permeability in a prostate cancer bone metastasis model following anti-platelet-derived growth factor receptor (PDGFR) therapy, indicating a drop in vascular endothelial growth factor receptor (VEGFR) activation [J] . Dafni H, Kim SJ, Bankson JA, Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine . 2008,第4期

机译：大分子动态对比增强（DCE）-MRI检测抗血小板源性生长因子受体（PDGFR）治疗后的前列腺癌骨转移模型中血管通透性降低，表明血管内皮生长因子受体（VEGFR）激活下降
4. An advanced bioengineered 3D model mimicking prostate cancer-induced bone metastasis microenvironment [C] . Ali Shokoohmand, Nathalie Bock, Judith A Clements, World biomaterials congress . 2016

机译：模仿前列腺癌诱发的骨转移微环境的先进生物工程3D模型
5. The role of insulin-like growth factor binding protein 3 and transforming growth factor beta in the metastasis of breast cancer to bone [D] . Giles, Erin D. 2007

机译：胰岛素样生长因子结合蛋白3和转化生长因子β在乳腺癌向骨转移中的作用
6. In Vitro Model of Metastasis to Bone Marrow Mediates Prostate Cancer Castration Resistant Growth through Paracrine and Extracellular Matrix Factors [O] . Reynald M. Lescarbeau, F. Philipp Seib, Marina Prewitz, -1

机译：转移的体外模型以通过旁分泌和细胞外基质因子骨髓介导前列腺癌去势抗性生长
7. Tea Polyphenols Decrease Serum Levels of Prostate-Specific Antigen, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor in Prostate Cancer Patients and Inhibit Production of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor In vitro [O] . Jerry McLarty, Rebecca L.H. Bigelow, Mylinh Smith, 2009

机译：茶多酚可降低前列腺癌患者中前列腺特异性抗原，肝细胞生长因子和血管内皮生长因子的血清水平，并抑制肝细胞生长因子和体外血管内皮生长因子的产生

Hepatocyte Growth Factor and Interleukin-6 in Prostate Cancer Bone Metastasis

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