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首页> 美国政府科技报告 >Prostaglandin E2 Receptor Expression by Osteoblasts is Modulated by Implant Surface Roughness and Prostaglandin E2
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Prostaglandin E2 Receptor Expression by Osteoblasts is Modulated by Implant Surface Roughness and Prostaglandin E2

机译：成骨细胞的前列腺素E2受体表达受植入物表面粗糙度和前列腺素E2的调节。

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While the predictability of dental implants is ever-increasing, the search for a more rapid and complete healing response, and thus earlier loading, is a much sought-after goal. Of prime importance in early wound healing is the inflammatory process, of which prostaglandins play a major role. Relatively little is known about the cellular receptors for prostaglandins, EP receptors, especially with regard to osteoblast response to implant surface roughness and early events preceding osseointegration. Four EP receptors have been elucidated- EP1, EP2, EP3, and EP4. These receptors play a critical role in both priming and attenuating the inflammatory response via the cAMP-mediated pathway, and thus are likely to be very important in the mechanisms of attachment, proliferation, and differentiation on the implant surfaces. Therefore, this study sought to further our understanding of the effects of PGE2 on EP receptor expression by osteoblasts cultured on titanium surfaces of varying roughness. Specifically, the aim of this study was to characterize EP receptor expression as a function of both titanium surface roughness and PGE2.

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