• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Genetic Analysis of DNA Repair Deficiency in Novel Non-Tumor Adjacent and Tumor Cell Lines Suggests a New Paradigm of Breast Cancer Etiology
【24h】

Genetic Analysis of DNA Repair Deficiency in Novel Non-Tumor Adjacent and Tumor Cell Lines Suggests a New Paradigm of Breast Cancer Etiology

机译：新型非肿瘤相邻和肿瘤细胞系DNa修复缺陷的遗传分析表明乳腺癌病因学的新范式

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have found that 75% of our NTA primary cultures (n= 42) and cell lines manifest the same deficiency of Nucleotide Excision Repair (NER) as the matching tumor culture. This subpopulation of breast cancers indicates that the loss of NER preceded the final mutations that led to full blown transformation. This hypothesis is in stark contrast to the hypothesis that cancer essentially arises in a vacuum and the NTA tissue represents relatively normal tissue. We will use the isogenic pairs of cell lines we have established to determine whether loss of NER in the pairs is: 1. due to reduced expression of the same genes in tumor vs NTA; 2. due to the loss of expression from an epigenetic phenomenon; or 3. due to the loss of expression from a genetic phenomenon, i.e. actual mutation of these genes.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号