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首页> 美国政府科技报告 >Disruption of Dopaminergic and Cholinergic Function in Military Deployment Implications to Parkinson's Disease
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Disruption of Dopaminergic and Cholinergic Function in Military Deployment Implications to Parkinson's Disease

机译：军事部署对帕金森病的多巴胺能和胆碱能功能的破坏

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The goal of this project is to evaluate the potential of pesticides and other compounds used by the military for their potential to damage the brain dopamine system and increase the risk for Parkinson's disease. Notable research accomplishments over the past year include the following: Deltamethrin increased the expression of DAT, TH, and VMAT2, locomotor activity in C57BL mice exposed during development. We further identified transcription factors that underlie this altered exposure. We also showed the pyrethroid treated mice exhibit altered response to cocaine and amphetamine. Deltamethrin did not exacerbate the toxicity to the dopamine neurotoxin MPTP either given before or after MPTP. Thus, with all of the compounds studied we have not observed toxicity consistent with a compound that would be thought to cause overt damage to the dopamine system. However, we have seen alterations of the dopamine system that must be studied further. The completion of this study will reveal the impact of militarily relevant agents on the pathogenesis of Parkinson's disease and response to psychostimulants and hopefully lead to strategies and policies that reduce the incidence of the disease.

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