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Ebola Virus: The Role of Macrophages and Dendritic Cells in the Pathogenesis of Ebola Hemorrhagic Fever

机译：埃博拉病毒：巨噬细胞和树突状细胞在埃博拉出血热发病机制中的作用

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Ebola hemorrhagic fever is a severe viral infection characterized by fever, shock and coagulation defects. Recent studies in macaques show that major features of illness are caused by effects of viral replication on microphages and dendritic cells. Infected macrophages produce proinflammatory cytokines, chemokines and tissue factor, attracting additional target cells and inducing vasodilation, increased vascular permeability and disseminated intravascular coagulation. However, they cannot restrict viral replication, possibly because of suppression of interferon responses. In consequence, virus disseminates to these and other cell types throughout the body, causing multifocal necrosis and a syndrome resembling septic shock. Massive 'bystander' apoptosis of natural killer and T cells further impairs immunity. These findings suggest that modifying host responses would be an effective therapeutic strategy, and treatment of infected macaques with a tissue-factor inhibitor reduced both inflammation and viral replication and improved survival.

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作者
Bray, M. ; Geisbert, T. W.;
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年度 2005
页码 1-8
总页数 8
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Ebola virus; Illness; Therapy; T lymphocytes; Hemorrhagic fevers; Immunity; Cells(Biology); Dendritic structure; Macrophages; Shock(Pathology); Necrosis; Blood coagulation; Macaque monkeys;

机译：埃博拉病毒;疾病;治疗; T淋巴细胞;出血热;免疫;细胞（生物学）;树突结构;巨噬细胞;休克（病理学）;坏死;血液凝固;猕猴;

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专利

1. Detection of Ebola Virus in Oral Fluid Specimens during Outbreaks of Ebola Virus Hemorrhagic Fever in the Republic of Congo [J] . Pierre Formenty, Eric Maurice Leroy, Alain Epelboin, Clinical Infectious Diseases . 2006,第11期

机译：刚果共和国爆发埃博拉病毒出血热期间口服液标本中的埃博拉病毒检测
2. Rapid Detection and Quantification of RNA of Ebola and Marburg Viruses, Lassa Virus, Crimean-Congo Hemorrhagic Fever Virus, Rift Valley Fever Virus, Dengue Virus, and Yellow Fever Virus by Real-Time Reverse Transcription-PCR [J] . Christian Drosten, Stephan G?ttig, Stefan Schilling, Journal of Clinical Microbiology . 2002,第7期

机译：通过实时逆转录PCR快速检测和定量埃博拉和马尔堡病毒，拉沙病毒，克里米亚刚果出血热病毒，裂谷热病毒，登革热病毒和黄热病病毒的RNA
3. Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance [J] . Rasmussen Angela L., Okumura Atsushi, Ferris Martin T., Science . 2014,第6212期

机译：宿主遗传多样性使埃博拉出血热的发病机理和耐药性得以实现
4. Development of Ebola Vaccine Candidate by in Silico from Glikoprotein (GP) Gene of Ebola Zaire Virus [C] . Yani Suryani, Opik Taupiqurrohman, Sri Aryanti, International Conference on Computation in Science and Engineering . 2017

机译：埃博拉扎伊尔病毒神经胶蛋白（GP）基因硅藻土的开发
5. Pathogenesis of ebola hemorrhagic fever in primate models in vivo and in vitro. [D] . Geisbert, Thomas W. 2003

机译：灵长类动物体内和体外埃博拉出血热的发病机理。
6. Rapid Detection and Quantification of RNA of Ebola and Marburg Viruses Lassa Virus Crimean-Congo Hemorrhagic Fever Virus Rift Valley Fever Virus Dengue Virus and Yellow Fever Virus by Real-Time Reverse Transcription-PCR [O] . Christian Drosten, Stephan Göttig, Stefan Schilling, 2002

机译：实时逆转录PCR快速检测和定量埃博拉病毒和马尔堡病毒拉沙病毒克里米亚刚果出血热病毒裂谷热病毒登革热病毒和黄热病病毒的RNA
7. Rapid Detection and Quantification of RNA of Ebola and Marburg Viruses, Lassa Virus, Crimean-Congo Hemorrhagic Fever Virus, Rift Valley Fever Virus, Dengue Virus, and Yellow Fever Virus by Real-Time Reverse Transcription-PCR [O] . Drosten, Christian, Göttig, Stephan, Schilling, Stefan, 2002

机译：通过实时逆转录PCR快速检测和定量埃博拉和马尔堡病毒，拉沙病毒，克里米亚刚果出血热病毒，裂谷热病毒，登革热病毒和黄热病病毒的RNA

Ebola Virus: The Role of Macrophages and Dendritic Cells in the Pathogenesis of Ebola Hemorrhagic Fever

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