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首页> 美国政府科技报告 >Comparison of Demineralized Dentin and Demineralized Freeze Dried Bone as Carriers for Enamel Matrix Proteins in a Rat Critical Size Defect
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Comparison of Demineralized Dentin and Demineralized Freeze Dried Bone as Carriers for Enamel Matrix Proteins in a Rat Critical Size Defect

机译：脱钙牙本质和脱钙冷冻干燥骨作为大鼠临界尺寸缺损牙釉质基质蛋白载体的比较

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This study evaluated the ability of Emdogain (EMD) in combination with demineralized freeze dried bone (DFDBA) or demineralized dentin matrix (DDM) to enhance bone regeneration as well as the ability of these carriers to maintain EMD at the surgical site. Critical size defects were created in rat calvaria. In Part I of the experiments, varying amounts of EMD (1 mg, 3 mg, 9 mg) with DFDBA or DDM were placed in the defects. DFDBA, DDM, EMD alone, and propylene glycol served as controls (8 rats/group). Rats were euthanized at two and eight weeks. Histological analysis was used to score for the presence of carrier material and new bone formation. The data were analyzed using RIDIT analysis.

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