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EGF Regulation of VEGF: Role in Progression of ErbB2 Overexpressing Mammary Tumors

机译：EGF对VEGF的调节：在过表达ErbB2的乳腺肿瘤中的作用

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Progression of breast tumors is dependent on blood vessel infiltration to supply nutrients and remove wastes. Expression of the angiogenic molecule vascular endothelial growth factor (VEGF) is a critical component of normal and pathological tissue vascularization. ErbB2, an epidermal growth factor receptor family member whose overexpression in mammary tumors is correlated with poor patient prognosis, has been previously implicated as a positive modulator of VEGF expression. I utilized a normal mouse mammary cell line (HC11) transfected with ErbB2 expression vectors to study the effects of ErbB2 overexpression on VEGF regulation. I have identified the promoter regions through which ErbB2 overexpression regulates VEGF expression by completing a structure-function analysis of the VEGF promoter in cultured mammary cells that overexpress ErbB2. ErbB2-mediated upregulation of VEGF involves at least two distinct promoter elements. One previously identified as the hypoxia responsive element and the other being the basal promoter region of the VEGF gene consisting of two adjacent SP1 transcription factor binding sites.

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作者
Loureiro, R. M. ; D'Amore, P. A.;
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年度 2004
页码 1-45
总页数 45
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Genes; Endothelium; Angiogenesis; Tissues(Biology); Predictions; Proteins; Nutrients; In vitro analysis; Infiltration(Fluids); Hypoxia; Pathology; Patients; Cells(Biology); Blood vessels; Epidermis; Mammary glands; Growth(Physiology); Metastasis;

机译：基因;内皮;血管生成;组织（生物学）;预测;蛋白质;营养素;体外分析;浸润（流体）;缺氧;病理学;患者;细胞（生物学）;血管;表皮;乳腺;生长（生理学）;转移;

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专利

1. β1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression [J] . L. Huck, S. M. Pontier, D. M. Zuo, Proceedings of the National Academy of Sciences of the United States of America . 2010,第35期

机译：β1整合素可诱导ErbB2乳腺肿瘤，但在肿瘤进展的转移阶段起关键作用
2. The Role of the VEGF-C/VEGFRs Axis in Tumor Progression and Therapy [J] . Chih-Chen Hong, Jen-Liang Su, Jui-Chieh Chen, International Journal of Molecular Sciences . 2012,第1期

机译：VEGF-C / VEGFRs轴在肿瘤进展和治疗中的作用
3. Increased expressions of vascular endothelial growth factor (VEGF), VEGF-C and VEGF receptor-3 in prostate cancer tissue are associated with tumor progression [J] . Jie Yang, Hong-Fei Wu, Li-Xin Qian, Asian Journal of Andrology . 2006,第2期

机译：前列腺癌组织中血管内皮生长因子（VEGF），VEGF-C和VEGF受体3的表达增加与肿瘤进展有关
4. VEGF-C, VEGF-D, and VEGFR-3 and their roles in lymphatic metastasis of tumors [C] . Wang Jian, Zhang Shi-Qian 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：VEGF-C，VEGF-D和VEGFR-3及其在肿瘤淋巴转移中的作用
5. Bone marrow-derived myeloid cell regulation of tumor angiogenesis and metastatic progression: Roles of VEGFR1 and CXCL4. [D] . Wels, Jared. 2011

机译：肿瘤血管生成和转移进程的骨髓来源的髓样细胞调节：VEGFR1和CXCL4的作用。
6. β1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression [O] . L. Huck, S. M. Pontier, D. M. Zuo, 2010

机译：β1整合素可诱导ErbB2乳腺肿瘤但在肿瘤进展的转移阶段起关键作用
7. β1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression [O] . Huck, L., Pontier, S. M., Zuo, D. M., 2010

机译：β1整合素可诱导ErbB2乳腺肿瘤，但在肿瘤进展的转移阶段起关键作用

EGF Regulation of VEGF: Role in Progression of ErbB2 Overexpressing Mammary Tumors

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