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Demyelination as a Target for Cell-Based Therapy of Chronic Blast-Induced Traumatic Brain Injury.

机译：脱髓鞘作为慢性疾病引起的创伤性脑损伤的细胞治疗靶点。

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The burden of traumatic brain injury (TBI) is expressed in the disabling behavioral and cognitive abnormalities noted in significant number of combat veterans. These clinical phenotypes suggest impairment in distributed cerebral functions dependent on the integrity of white matter (WM) tracts. In this proposal we explore mechanisms of mild blast trauma-associated demyelination, with the goal of testing a therapeutic strategy to enhance remyelination using human glial restricted progenitors (hGRPs; Q Therapeutics Inc.).

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作者
Janowski, M.;
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年度 2014
页码 1-15
总页数 15
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
STEM CELLS; TRAUMATIC BRAIN INJURIES; BLAST; MAGNETIC RESONANCE IMAGING; MORTALITY RATE; TBI(TRAUMATIC BRAIN INJURIES); WM(WHITE MATTER); DEMYELINATION; REMYELINATION; HGRP(HUMAN GLIAL RESTRICTED PROGENITORS); MYELIN; BLAST INJURIES; MRI(MAGNETIC RESONANCE IMAGING);

机译：干细胞;创伤性脑损伤;爆发;磁共振成像;死亡率; TBI（创伤性脑损伤）; Wm（白质）;脱髓鞘;重新激活; HGRp（人类受限制的受累者）; mYELIN; BLasT伤害; mRI（磁共振）成像）;

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专利

1. Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury. [J] . Readnower RD, Chavko M, Adeeb S, Journal of Neuroscience Research . 2010,第16期

机译：在爆炸诱导的颅脑外伤大鼠模型中，血脑屏障通透性，氧化应激和活化的小胶质细胞增加。
2. Visual dysfunctions and symptoms during the subacute stage of blast-induced mild traumatic brain injury. [J] . José E Capó-Aponte, Thomas G Urosevich, Leonard A Temme, Military Medicine: Official Journal of AMSUS, The Society of the Federal Health Agencies . 2012,第7期

机译：爆炸诱导的轻度颅脑外伤亚急性期的视觉功能障碍和症状。
3. A mouse model of blast-induced mild traumatic brain injury. [J] . Rubovitch V, Ten Bosch M, Zohar O, Experimental Neurology . 2011,第2期

机译：爆炸诱发的轻度颅脑损伤的小鼠模型。
4. Transcranial LED therapy for cognitive dysfunction in chronic, mild traumatic brain injury: Two case reports [C] . Margaret A. Naeser, Anita Saltmarche, Maxine H. Krengel, Mechanisms for low-light therapy V . 2010

机译：经颅LED疗法治疗慢性轻度脑外伤的认知功能障碍：两例报告
5. Blood-Brain Barrier Dysfunction and Repair after Blast-Induced Traumatic Brain Injury. [D] . Hue, Christopher Donald. 2015

机译：爆炸诱发的颅脑外伤后的血脑屏障功能障碍和修复。
6. Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post traumatic stress disorder: a case report [O] . Paul G Harch, Edward F Fogarty, Paul K Staab, 2009

机译：低压高压氧治疗和SPECT脑成像在爆炸性慢性创伤性脑损伤（脑震荡后综合征）和创伤后应激障碍中的治疗：病例报告
7. Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post traumatic stress disorder: a case report [O] . Paul G Harch, Edward F Fogarty, Paul K Staab, 2012

机译：低压高压氧治疗和SPECT脑成像在爆炸性慢性创伤性脑损伤（脑震荡后综合征）和创伤后应激障碍中的治疗：病例报告
8. Demyelination as a Target for Cell-Based Therapy of Chronic Blast-Induced Traumatic Brain Injury. [R] . Walczak, P. 2014

机译：脱髓鞘作为慢性疾病引起的创伤性脑损伤的细胞治疗靶点。

Demyelination as a Target for Cell-Based Therapy of Chronic Blast-Induced Traumatic Brain Injury.

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